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期刊论文 [26]
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EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma
期刊论文
HAEMATOLOGICA, 2020, 卷号: 105, 期号: 4, 页码: 1021-1031
作者:
Xie, Shao
;
Wei, Fan
;
Sun, Yi-ming
;
Gao, Ying-lei
;
Pan, Lu-lu
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 1, 页码: 58-63
作者:
Zhu, Kongkai
;
Du, Daohai
;
Yang, Rui
;
Tao, Hongrui
;
Zhang, Hua
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
polycomb repressive complex 2
EZH2-EED interaction inhibitor
virtual screening
molecular dynamics simulation
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:
Shi, Yi
;
Ma, Hong-lei
;
Zhuang, You-wen
;
Wang, Xiao-xi
;
Jiang, Yi
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
Inhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3
期刊论文
STEM CELLS AND DEVELOPMENT, 2019, 卷号: 28, 期号: 10, 页码: 649-658
作者:
Hong, Feng
;
Zhao, Mengxue
;
Zhang, Lei
;
Feng, Linyin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
dopaminergic neurons
Ezh2
Nurr1
neural stem cells
c10orf12modulatesprc2histonemethyltransferaseactivityandh3k27me3levels
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1457
作者:
Shi Yi
;
Ma Honglei
;
Zhuang Youwen
;
Wang Xiaoxi
;
Jiang Yi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
REPRESSIVE COMPLEX 2
GENOMIC TARGETS
POLYCOMB
PROTEIN
CHROMATIN
RECRUITMENT
JARID2
DIFFERENTIATION
BINDING
METHYLATION
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells
期刊论文
Cellular Signalling, 2018
作者:
Xiong Liu
;
Chun Li
;
Rendong Zhang
;
Wenjun Xiao
;
Xia Niu
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/31
Structure of the PRC2 complex and application to drug discovery
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 963-976
作者:
Shi, Yi
;
Wang, Xiao-xi
;
Zhuang, You-wen
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
PRC2
histone methyltransferase
H3K27me3
nucleosome
structure
drug discovery
structureoftheprc2complexandapplicationtodrugdiscovery
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 7, 页码: 963
作者:
Shi Yi
;
Wang Xiaoxi
;
Zhuang Youwen
;
Jiang Yi
;
Melcher Karsten
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
PRC2
histone methyltransferase
H3K27me3
nucleosome
structure
drug discovery
Tetrahymena australis (Protozoa, Ciliophora): A Well-Known But "Non-Existing" Taxon - Consideration of Its Identification, Definition and Systematic Position
期刊论文
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2016, 卷号: 63, 期号: 6, 页码: 760-770
作者:
Liu, Mingjian
;
Fan, Xinpeng
;
Gao, Feng
;
Gao, Shan
;
Yu, Yuhe
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/11/14
cox1 gene
cryptic species
SSU rRNA gene
Tetrahymena pyriformis complex
Tetrahymena australis (Protozoa, Ciliophora): A Well-Known But "Non-Existing" Taxon - Consideration of Its Identification, Definition and Systematic Position
期刊论文
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2016, 卷号: 63, 期号: 6, 页码: 760-770
作者:
Liu, Mingjian
;
Fan, Xinpeng
;
Gao, Feng
;
Gao, Shan
;
Yu, Yuhe
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2016/12/16
cox1 gene
cryptic species
SSU rRNA gene
Tetrahymena pyriformis complex
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