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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 专题：山东大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 73-86 作者:  Zhao, Wei;  He, Long;  Xiang, Tian-Le;  Tang, Ya-Jie 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/11 Tubulin  Colchicine domain  Podophyllotoxin  Binding affinity  Nanomolar-potency antitumor activity   Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties 期刊论文 Investigational New Drugs, 2019 作者:  Wu J.-D.;  Cui Y.-J.;  Zhou Y.-G.;  Tang L.-Q.;  Zhang C.-M. 收藏  |  浏览/下载：11/0  |  提交时间：2019/12/11 Hepatocellular carcinoma  Liver microsome stability  Multidrug-resistance  Pharmacokinetics  Tubulin polymerization inhibitor   Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations 期刊论文 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 7, 页码: 659-664 作者:  Liu, Guangpu;  Jiao, Yang;  Huang, Chunxi;  Chang, Ping 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 Microtubules inhibitors  Anticancer target  Colchicine binding site  Drug discovery  Molecular docking   Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain 期刊论文 European Journal of Medicinal Chemistry, 2019, 页码: 73-86 作者:  Zhao W.;  He L.;  Xiang T.-L.;  Tang Y.-J. 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 Binding affinity  Colchicine domain  Nanomolar-potency antitumor activity  Podophyllotoxin  Tubulin   Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site 期刊论文 MOLECULES, 2016, 卷号: 21, 期号: 10 作者:  Dong, Mengqi;  Liu, Fang;  Zhou, Hongyu;  Zhai, Shumei;  Yan, Bing 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/16 tubulin inhibitors  microtubule dynamics  antimitotic  multidrug  resistance   Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 11, 页码: 5341-5355 作者:  Liu, Yan-Na;  Wang, Jing-Jing;  Ji, Ya-Ting;  Zhao, Guo-Dong;  Tang, Long-Qian 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/17 Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments 期刊论文 CURRENT MEDICINAL CHEMISTRY, 2015, 卷号: 22, 期号: 11, 页码: 1348-1360 作者:  Ji, Ya-Ting;  Liu, Yan-Na;  Liu, Zhao-Peng 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/17 Anticancer  antitumor  antivascular  clinical trials  colchicine binding  site  tubulin inhibitors  vascular disrupting agents (VDAs)