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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang
收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640
作者:  Zhang, Shiyan;  Lou, Jianfeng;  Li, Yafang;  Zhou, Feilong;  Yan, Ziqin
收藏  |  浏览/下载：64/0  |  提交时间：2021/11/04
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng
收藏  |  浏览/下载：46/0  |  提交时间：2021/08/17
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation 期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11
作者:  Bao, Weilian;  Liu, Xiaohong;  You, Yan;  Hou, Hui;  Wang, Xu
收藏  |  浏览/下载：58/0  |  提交时间：2021/11/16
The ups, downs and new trends of IDO1 inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 12
作者:  Chen, Shulun;  Tan, Jing;  Zhang, Ao
收藏  |  浏览/下载：14/0  |  提交时间：2021/08/17
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function 期刊论文
MOLECULAR CANCER THERAPEUTICS, 2020, 卷号: 19, 期号: 11, 页码: 2340-2352
作者:  Jin, Rui;  Liu, Liang;  Xing, Yun;  Meng, Tao;  Ma, Lanping
收藏  |  浏览/下载：50/0  |  提交时间：2020/12/24
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao
收藏  |  浏览/下载：28/0  |  提交时间：2020/12/21
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao
收藏  |  浏览/下载：23/0  |  提交时间：2020/12/21
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:  Sun, Shui-mei;  Xie, Zhi-fu;  Zhang, Yang-ming;  Zhang, Xin-wen;  Zhou, Chen-dong
收藏  |  浏览/下载：25/0  |  提交时间：2020/12/24

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