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Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 10, 页码: 2260-2269
作者:
Yin, Jianpeng
;
Zhan, Desheng
;
Ma, Hui
;
Liu, Huanan
;
Yu, Lifang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/12/16
YLF466D
AMPK activator
glucose metabolism
lipid metabolism
MIRI
domino reaction
C-H activation
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 149
作者:
Zhang, Wang
;
Li, Jing-Ya
;
Wei, Xiao-Chen
;
Wang, Qian
;
Yang, Ji-Yang
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  |  
浏览/下载:56/0
  |  
提交时间:2021/04/26
DBP
PPAR alpha
AMPK
Lipid metabolism
Liver function
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice
期刊论文
DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988
作者:
Xu, Xu
;
Wang, Wei
;
Wang, Zhengyu
;
Lv, Jianlu
;
Xu, Xiaoju
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
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  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Insight into AMPK regulation mechanism in vivo and in vitro: Responses to low temperatures in the olive flounder Paralichthys olivaceus
期刊论文
JOURNAL OF THERMAL BIOLOGY, 2020, 卷号: 91, 页码: 9
作者:
Nie, Miaomiao
;
Lu, Yunliang
;
Zou, Congcong
;
Wang, Lijuan
;
Zhang, Peijun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/09/25
Paralichthys olivaceus
AMPK pathway
Cold stress
Activator
Inhibitor
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
期刊论文
CELL METABOLISM, 2019, 卷号: 30, 期号: 3, 页码: 508-+
作者:
Li, Mengqi
;
Zhang, Chen-Song
;
Zong, Yue
;
Feng, Jin-Wei
;
Ma, Teng
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  |  
浏览/下载:153/0
  |  
提交时间:2019/12/02
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
作者:
Li, Yingying
;
Peng, Jiale
;
Li, Penghua
;
Du, Haibo
;
Li, Yaping
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2019/07/29
Pharmacophore modeling
Molecular docking
Quantitative structure activity relationship (QSAR)
Molecular dynamics
AMPK
Activator
Synthesis and structure-activity relationships of pyrazolo-[3,4-b]pyridine derivatives as adenosine 5'-monophosphate-activated protein kinase activators
期刊论文
ARCHIV DER PHARMAZIE, 2019, 卷号: 352, 期号: 8
作者:
Zheng, Bifeng
;
Peng, Yajun
;
Wu, Weihong
;
Ma, Junlong
;
Zhang, Yuzhao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/11
activator
AMPK
cell proliferation
molecular docking
pyrazolo[3
4-b]pyridine
A novel AMPK activator improves hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis
期刊论文
2019, 卷号: 140, 期号: 2, 页码: 153-161
作者:
Peng, Xueying
;
Li, Jin
;
Wang, Minjie
;
Qu, Kai
;
Zhu, Haibo
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
AMPK activator
Hepatic lipid metabolism
Leukocyte trafficking
Hepatic steatosis
Inflammation
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