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科研机构
上海药物研究所 [322]
内容类型
期刊论文 [321]
会议论文 [1]
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2021 [26]
2020 [34]
2019 [26]
2018 [23]
2017 [32]
2016 [25]
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Chemistry [4]
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Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 页码: 12
作者:
Xue, Haitao
;
Guo, Shuang
;
Hu, Tianwen
;
Wei, Daibao
;
Xie, Yuanchao
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/01/18
2 '-deoxy carbocyclic nucleoside
antiviral activity
hepatitis B virus
Mitsunobu reaction
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Genetically-engineered "all-in-one" vaccine platform for cancer immunotherapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 11, 页码: 3622-3635
作者:
Wu, Aihua
;
Chen, Yingzhi
;
Wang, Hairui
;
Chang, Ya
;
Zhang, Meng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
Trichosanthin
Legumain
TRP2
Transcutaneous immunization
Adjuvant
Cancer vaccine
Protein engineering
Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2021, 页码: 14
作者:
Duan, Nianxiu
;
Li, Junjun
;
Song, Sha
;
Wang, Feng
;
Yang, Yiwei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/11/04
drug delivery
pancreatic cancer
prodrugs
smart liposomes
tumor-specific vascular promotion
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Detachable Liposomes Combined Immunochemotherapy for Enhanced Triple-Negative Breast Cancer Treatment through Reprogramming of Tumor-Associated Macrophages
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 14, 页码: 6031-6041
作者:
Chen, Mingshu
;
Miao, Yunqiu
;
Qian, Kun
;
Zhou, Xin
;
Guo, Linmiao
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/11/04
Immunochemotherapy
triple-negative breast cancer
liposomes
tumor-associated macrophages
MMP2 response
Synthesis and biological evaluation of novel cabazitaxel analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 41, 页码: 12
作者:
Ren, Sumei
;
Zhang, Minmin
;
Wang, Yujie
;
Guo, Jia
;
Wang, Junfei
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/08/17
Tritium extraction
Hydrogen isotopes
Eutectic Pb-Li
Fusion fuel cycle
Cabazitaxel
Docetaxel
Taxel
Anticancer
Semi-synthesis
10-Deacetylbaccatin III
Cytotoxicity
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation
期刊论文
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021, 页码: 15
作者:
Chen, Li
;
Zhao, Shuang
;
Zhu, Yanyan
;
Liu, Yongsheng
;
Li, Huiyu
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/08/17
STING
Small molecule
Binding site
Modulated mechanism
Molecular dynamics simulation
pi-pi stacking interaction
Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2021, 卷号: 31, 期号: 26, 页码: 30
作者:
Wang, Weiqi
;
Jin, Yilan
;
Liu, Xiao
;
Chen, Fangmin
;
Zheng, Xiaohua
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
cancer immunotherapy
immune diagnosis
nanomedicine
stimuli-responsive
tumor microenvironment
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