Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer

doi:10.1002/adfm.202100386

	Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer
	Wang, Weiqi 1,2,3; Jin, Yilan 1,2,3; Liu, Xiao 1; Chen, Fangmin 2,3; Zheng, Xiaohua 1; Liu, Tianqing 4; Yang, Yumin 5,6; Yu, Haijun 2,3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2021-06-01
卷号	31 期号:26 页码:30
关键词	cancer immunotherapy immune diagnosis nanomedicine stimuli-responsive tumor microenvironment
ISSN号	1616-301X
DOI	10.1002/adfm.202100386
通讯作者	Yang, Yumin(yangym@ntu.edu.cm) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	Cancer immunotherapy has witnessed significant advances in the past decade, however challenges associated with immune-related adverse effects and immunosuppressive tumor microenvironment, have hindered their clinical application. Stimuli-activatable nanomedicines hold great potential for improving the efficiency of cancer immunotherapy and minimizing the side effects via tumor-specific accumulation, controllable drug release profile, and combinational therapy by integrating multiple therapeutic regimens. In this review, the recent advances of stimuli-activatable nanomedicines for cancer immunotherapy are first described, with particular focus on endogenous stimuli including pH, glutathione, reactive oxygen species, and excessive enzymes within the tumor microenvironment. Then, the endogenous stimuli-activatable nanomedicines that target tumor cells, immune cells, or periphery immune systems for eliciting sustained systemic immune activation and modulating the immunosuppressive tumor microenvironment, are described. Next, the general mechanisms underlying nanomedicine-based immunotherapy by eliciting anti-tumor immune responses and overcoming immunologic tolerance are described. Further, the emerging application of bioimaging techniques for monitoring immune response and evaluating therapy performance is described. Finally, the authors' perspectives are provided for the clinical translation of nanomedicine-based cancer immunotherapy.
WOS关键词	IMMUNOGENIC CELL-DEATH ; TUMOR-ASSOCIATED MACROPHAGES ; REGULATORY T-CELLS ; EXTRACELLULAR-MATRIX ; ANTITUMOR IMMUNITY ; CHECKPOINT BLOCKADE ; SUPPRESSOR-CELLS ; PHOTODYNAMIC THERAPY ; DENDRITIC CELLS ; IMMUNOTHERAPY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000665207900041
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296840]
专题	中国科学院上海药物研究所
通讯作者	Yang, Yumin; Yu, Haijun
作者单位	1.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW 2145, Australia 5.Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, Nantong 226001, Peoples R China 6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Minist Educ, Nantong 226001, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weiqi,Jin, Yilan,Liu, Xiao,et al. Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2021,31(26):30.
APA	Wang, Weiqi.,Jin, Yilan.,Liu, Xiao.,Chen, Fangmin.,Zheng, Xiaohua.,...&Yu, Haijun.(2021).Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer.ADVANCED FUNCTIONAL MATERIALS,31(26),30.
MLA	Wang, Weiqi,et al."Endogenous Stimuli-Activatable Nanomedicine for Immune Theranostics for Cancer".ADVANCED FUNCTIONAL MATERIALS 31.26(2021):30.