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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439 期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:  Shackleford, David M.;  Chiu, Francis C. K.;  Katneni, Kasiram;  Blundell, Scott;  McLaren, Jenna
收藏  |  浏览/下载:59/0  |  提交时间:2021/11/04
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:  Pan, Lu-lu;  Yang, Yong;  Hui, Min;  Wang, Shuo;  Li, Cui-yun
收藏  |  浏览/下载:82/0  |  提交时间:2020/12/24
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor 期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:  Zhang, Leduo;  Mao, Yu;  Gao, Zhiwei;  Chen, Xiaoyan;  Li, Xin
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/01
Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model 期刊论文
Xenobiotica; the fate of foreign compounds in biological systems, 2018, 页码: 1-14
作者:  Parmentier, Yannick;  Pothier, Corinne;  Hewitt, Nicola;  Vincent, Ludwig;  Caradec, Fabrice
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:  Zhu, Yunting;  Li, Liang;  Zhang, Ge;  Wan, Hong;  Yang, Changyong
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08
Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes 期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 5, 页码: 646-659
作者:  Meng, Jian;  Zhong, Dafang;  Li, Liang;  Yuan, Zhengyu;  Yuan, Hong
收藏  |  浏览/下载:18/0  |  提交时间:2019/01/08
Identification of Amino Acid and Glutathione N-Conjugates of Toosendanin: Bioactivation of the Furan Ring Mediated by CYP3A4 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 卷号: 27, 期号: 9, 页码: 1598-1609
作者:  Yu, Jinghua;  Deng, Pan;  Zhong, Dafang;  Chen, Xiaoyan
收藏  |  浏览/下载:14/0  |  提交时间:2019/01/08
Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation 期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 5, 页码: 872-884
作者:  Lin, Lishan;  Xie, Cen;  Gao, Zhiwei;  Chen, Xiaoyan;  Zhong, Dafang
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08
Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1 期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 4, 页码: 774-781
作者:  Diao, Xingxing;  Pang, Xiaoyan;  Xie, Cen;  Guo, Zitao;  Zhong, Dafang
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation 期刊论文
DRUG METABOLISM AND DISPOSITION, 2013, 卷号: 41, 期号: 2, 页码: 430-444
作者:  Diao, Xingxing;  Deng, Pan;  Xie, Cen;  Li, Xiuli;  Zhong, Dafang
收藏  |  浏览/下载:20/0  |  提交时间:2019/01/08


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