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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
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2021 [1]
2020 [2]
2018 [1]
2016 [1]
2015 [1]
2014 [3]
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内容类型:期刊论文
专题:上海药物研究所
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Pan, Lu-lu
;
Yang, Yong
;
Hui, Min
;
Wang, Shuo
;
Li, Cui-yun
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2020/12/24
forsythin
pharmacokinetics
drug metabolism
drug excretion
sulfation
glucuronidation
organic anion transporter 3
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model
期刊论文
Xenobiotica; the fate of foreign compounds in biological systems, 2018, 页码: 1-14
作者:
Parmentier, Yannick
;
Pothier, Corinne
;
Hewitt, Nicola
;
Vincent, Ludwig
;
Caradec, Fabrice
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Pyrotinib
UPLC/Q-TOF MS
Metabolism
Human
CYP3A4
Drug-drug interaction
Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 5, 页码: 646-659
作者:
Meng, Jian
;
Zhong, Dafang
;
Li, Liang
;
Yuan, Zhengyu
;
Yuan, Hong
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  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Identification of Amino Acid and Glutathione N-Conjugates of Toosendanin: Bioactivation of the Furan Ring Mediated by CYP3A4
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 卷号: 27, 期号: 9, 页码: 1598-1609
作者:
Yu, Jinghua
;
Deng, Pan
;
Zhong, Dafang
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation
期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 5, 页码: 872-884
作者:
Lin, Lishan
;
Xie, Cen
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Zhong, Dafang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1
期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 4, 页码: 774-781
作者:
Diao, Xingxing
;
Pang, Xiaoyan
;
Xie, Cen
;
Guo, Zitao
;
Zhong, Dafang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation
期刊论文
DRUG METABOLISM AND DISPOSITION, 2013, 卷号: 41, 期号: 2, 页码: 430-444
作者:
Diao, Xingxing
;
Deng, Pan
;
Xie, Cen
;
Li, Xiuli
;
Zhong, Dafang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
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