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科研机构
上海药物研究所 [14]
中国科学院大学 [1]
内容类型
期刊论文 [15]
发表日期
2021 [3]
2019 [2]
2016 [3]
2015 [1]
2014 [1]
2013 [4]
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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
Pyrrolidinyl Synthetic Cathinones alpha-PHP and 4F-alpha-PVP Metabolite Profiling Using Human Hepatocyte Incubations
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 1, 页码: 17
作者:
Carlier, Jeremy
;
Diao, Xingxing
;
Giorgetti, Raffaele
;
Busardo, Francesco P.
;
Huestis, Marilyn A.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/05/24
alpha-PHP
PV7
4F-alpha-PVP
novel psychoactive substance
synthetic cathinone
bath salt
hepatocyte metabolism
liquid chromatography-high resolution tandem mass spectrometry
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:
Pan, Lulu
;
Guo, Shuang
;
Chen, Xiaoyan
;
Jiang, Xiangrui
;
Shen, Jingshan
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
TPNI71
Metabolism
UPLC/Q-TOF MS
High-resolution mass spectrometry
Metabolite identification
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 15
作者:
Diao, Xingxing
;
Huestis, Marilyn A.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
novel psychoactive substances
NPS
synthetic cannabinoid
SC
metabolism
urinary metabolites
hepatocyte incubation
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/05/09
Pyrotinib
Uplc/q-tof ms
Metabolism
Human
Cyp3a4
Drug-drug interaction
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Pyrotinib
UPLC/Q-TOF MS
Metabolism
Human
CYP3A4
Drug-drug interaction
Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 卷号: 10, 页码: 2181-2191
作者:
Jiang, Jinfang
;
Pang, Xuehai
;
Li, Liang
;
Dai, Xiaojian
;
Diao, Xingxing
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
enzalutamide
N-methyl deuteration
deuterium kinetic isotope effect
pharmacokinetics
isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1520
作者:
Diao Xingxing
;
Zhong Kan
;
Li Xiuli
;
Zhong Dafang
;
Chen Xiaoyan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
CANCER RESISTANCE PROTEIN
P-GLYCOPROTEIN P-GP/ABCB1
TANDEM MASS-SPECTROMETRY
FOCAL CEREBRAL-ISCHEMIA
PLASMA-PROTEIN
CHIRAL 3-N-BUTYLPHTHALIDE
TISSUE DISTRIBUTION
DRUG DISCOVERY
BINDING
PENETRATION
3-n-butylphthalide (NBP)
3-OH-NBP
10-OH-NBP
blood-brain barrier
isomer-selective
drug plasma protein binding
drug brain protein binding
P-gp/BCRP
cerebral ischemia
Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1
期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 4, 页码: 774-781
作者:
Diao, Xingxing
;
Pang, Xiaoyan
;
Xie, Cen
;
Guo, Zitao
;
Zhong, Dafang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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