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浏览/检索结果: 共39条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Lu, Yu-Ting;  Xiao, Yu-Feng;  Li, Yu-Feng;  Li, Jia;  Nan, Fa-Jun 收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08 Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812 作者:  Zheng, Qiangang;  Chen, Ziqi;  Wan, Huixin;  Tang, Shuai;  Ye, Yan 收藏  |  浏览/下载：234/0  |  提交时间：2019/01/08 IDH1 inhibitor  Imidazole cyclopropyl amine  Structure-based rational design   Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689 作者:  Wang, Qi;  Dai, Yang;  Ji, Yinchun;  Shi, Huanyu;  Guo, Zuhao 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791 作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 GPR40 agonist  2,3-Dihydrobenzo[b][1,4]dioxine  Insulin secretion  Type 2 diabetes mellitus   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds 期刊论文 Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1902-1912 作者:  Gong, Grace Qun;  Wang, Ke;  Dai, Xin-Chuan;  Zhou, Yan;  Basnet, Rajesh 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands 期刊论文 CHEMMEDCHEM, 2018, 卷号: 13, 期号: 22, 页码: 2455-2463 作者:  Qian, Hai-Yan;  Wang, Zhi-Long;  Chen, Li-Li;  Pan, You-Lu;  Xie, Xiao-Yu 收藏  |  浏览/下载：90/0  |  提交时间：2019/01/08 cannabinoids  CB1R  CB2R  heteroaryl pyrimidines  heteroaryl triazines  ligands   Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：86/0  |  提交时间：2019/01/08 Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204 作者:  Li, Daqiang;  Zhang, Xiaotuan;  Ma, Xiaodong;  Xu, Lei;  Yu, Jianjun 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship