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浏览/检索结果: 共31条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 24, 页码: 10231-10244 作者:  Liu, Qiufeng;  Huang, Fubao;  Yuan, Xiaojing;  Wang, Kai;  Zou, Yi 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270 作者:  Zhang, Wei-yao;  Lu, Wen-chao;  Jiang, Hao;  Lv, Zheng-bing;  Xie, Yi-qian 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 epigenetics  molecular docking  PRMT1  scaffold hopping  small-molecule inhibitor   Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464 作者:  Zhou, Shengbin;  Duan, Yanan;  Wang, Jiang;  Zhang, Jin;  Sun, Haifeng 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Tetrahydroberberine  4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines  Mitochondrial respiration  AMPK indirect activators  db/db mice   Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals 期刊论文 CRYSTENGCOMM, 2017, 卷号: 19, 期号: 41, 页码: 6154-6163 作者:  He, Hongyan;  Zhang, Qi;  Wang, Jian-Rong;  Mei, Xuefeng 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532 作者:  Chen, Wen-hua;  Song, Shan-shan;  Qi, Ming-hui;  Huan, Xia-juan;  Wang, Ying-qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PARP-1 inhibitor  olaparib  breast cancer  BRCA-deficient tumors   Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition 期刊论文 ONCOLOGY LETTERS, 2017, 卷号: 14, 期号: 4, 页码: 4294-4300 作者:  Shen, Lan;  Zhang, Fang;  Huang, Ruimin;  Yan, Jun;  Shen, Bing 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 honokiol  bladder cancer  cell invasion  steroid receptor coactivator-3  epithelial-mesenchymal transition  Twist1   Thermosensitive Liposomal Codelivery of HSA-Paclitaxel and HSA-Ellagic Acid Complexes for Enhanced Drug Perfusion and Efficacy Against Pancreatic Cancer 期刊论文 ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 30, 页码: 25138-25151 作者:  Wei, Yan;  Wang, Yuxi;  Xia, Dengning;  Guo, Shiyan;  Wang, Feng 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 pancreatic cancer  fibrotic matrix  pancreatic stellate cells  thermosensitive liposomes  codelivery  HSA-drug complexes  PSCs-PDA interaction   Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf(V600E) inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1059-1068 作者:  Wang, Gui-min;  Wang, Xiang;  Zhu, Jian-ming;  Guo, Bin-bin;  Yang, Zhuo 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 B-Raf(V600E) inhibitor  anticancer  vemurafenib  deazapurine  fragment reassembly  molecular docking  structure-activity relationship   A UPLC/MS/MS method for determination of protosappanin B in rat plasma and its application of a pharmacokinetic and bioavailability study 期刊论文 BIOMEDICAL CHROMATOGRAPHY, 2017, 卷号: 31, 期号: 7 作者:  Chen, Wei-Ying;  Zhou, Xian-Zhen;  Wu, Li-Lan;  Wu, Yun-Shan;  Wang, Shu-Mei 收藏  |  浏览/下载：228/0  |  提交时间：2019/01/08 Bioavailability  Pharmacokinetic  protosappanin B  UPLC-MS/MS   Modulating the Dissolution and Mechanical Properties of Resveratrol by Cocrystallization 期刊论文 CRYSTAL GROWTH & DESIGN, 2017, 卷号: 17, 期号: 7, 页码: 3989-3996 作者:  He, Hongyan;  Zhang, Qi;  Li, Meiqi;  Wang, Jian-Rong;  Mei, Xuefeng 收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08