Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition

doi:10.3892/ol.2017.6665

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 分子影像中心（筹）

	Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition
	Shen, Lan 1,3; Zhang, Fang 4; Huang, Ruimin2 ; Yan, Jun 1,3; Shen, Bing 4
刊名	ONCOLOGY LETTERS
	2017-10
卷号	14 期号:4 页码:4294-4300
关键词	honokiol bladder cancer cell invasion steroid receptor coactivator-3 epithelial-mesenchymal transition Twist1
ISSN号	1792-1074
DOI	10.3892/ol.2017.6665
文献子类	Article
英文摘要	Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition by induction of E-cadherin and repression of N-cadherin. Honokiol was capable of significantly downregulating the expression of cell invasion-associated genes, steroid receptor coactivator-3 (SRC-3), matrix metalloproteinase (MMP) -2 and Twist1. Notably, the inhibition of UBC cell invasion by honokiol was reversed by reintroduction of oncoprotein SRC-3 expression, with the restoration of MMP-2 and Twist1, and reduction of E-cadherin expression. Furthermore, the results of the luciferase assay confirmed that SRC-3 could regulate Twist1 promoter activity. Taken together, the results of the present study suggest that honokiol is a promising agent against UBC cell invasion via downregulation of SRC-3 and its target genes.
资助项目	National Natural Science Foundation of China[81372168] ; National Natural Science Foundation of China[81572519] ; National Natural Science Foundation of China[81470116] ; Natural Science Foundation for Universities in Jiangsu Province of China[BK20151396] ; Wu Jieping Medical Foundation[320.6750.16051] ; 'one hundred talent program' of Chinese Academy of Sciences[00000000] ; State Key Laboratory of Drug Research[SIMM1705KF-06] ; Shanghai Natural Science Foundation of China[14ZR1433200]
WOS关键词	STEROID-RECEPTOR COACTIVATORS ; LUNG-CANCER ; PROLIFERATION ; METASTASIS ; AIB1 ; SURVIVAL ; BREAST ; OVEREXPRESSION ; CARCINOMA ; APOPTOSIS
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000413151300057
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272470]
专题	分子影像中心（筹）中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yan, Jun; Shen, Bing
作者单位	1.Nanjing Univ, Model Anim Res Ctr, MOE, Key Lab Model Anim Dis Study, 12 Xuefu Rd, Nanjing 210061, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ, Model Anim Res Ctr, State Key Lab Pharmaceut Biotechnol, 12 Xuefu Rd, Nanjing 210061, Jiangsu, Peoples R China; 4.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Urol, 100 Haining Rd, Shanghai 200080, Peoples R China;
推荐引用方式 GB/T 7714	Shen, Lan,Zhang, Fang,Huang, Ruimin,et al. Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition[J]. ONCOLOGY LETTERS,2017,14(4):4294-4300.
APA	Shen, Lan,Zhang, Fang,Huang, Ruimin,Yan, Jun,&Shen, Bing.(2017).Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition.ONCOLOGY LETTERS,14(4),4294-4300.
MLA	Shen, Lan,et al."Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition".ONCOLOGY LETTERS 14.4(2017):4294-4300.