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湖南大学 [5]
北京大学 [1]
兰州理工大学 [1]
兰州大学 [1]
心理研究所 [1]
昆明植物研究所 [1]
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期刊论文 [16]
学位论文 [1]
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2014 [17]
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Chemistry [1]
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发表日期:2014
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二恶英对乙酰胆碱酯酶活性的影响及分子机制
学位论文
博士, 北京: 中国科学院研究生院, 2014
作者:
徐海明
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2016/08/10
二恶英,乙酰胆碱酯酶,芳香烃受体,转录调控,神经元,dioxins
acetylcholinesterase
aryl hydrocarbon receptor
transcriptional regulation
neuron
Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
期刊论文
BRAIN RESEARCH, 2014, 卷号: 1589, 期号: 1589, 页码: 105-111
作者:
Shao, Shuang
;
Li, Man
;
Du, Wei
;
Shao, Feng
;
Wang, Weiwen
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2015/09/18
Adolescence
MK-801
Social isolation
Galanthamine
Prepulse inhibition
Chemical Constituents from the Stems of Excoecaria acertiflia
期刊论文
CHEMISTRY & BIODIVERSITY, 2014, 卷号: 11, 期号: 9, 页码: 1406-1416
作者:
Huang, Sheng-Zhuo
;
Luo, Huai-Rong
;
Ma, Qing-Yun
;
Peng, Hua
;
Dai, Hao-Fu
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2014/11/25
ACETYLCHOLINESTERASE INHIBITORS
ACERIFOLIA
SESQUITERPENOIDS
LIGNANS
ABIES
Synthesis and structure-activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2014, 卷号: 23, 期号: 6
-
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2014/12/05
Aporphine alkaloids
Acetylcholinesterase inhibitors
Structure-activity relationships
Synthesis and structure-activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2014, 卷号: 23, 期号: 6, 页码: 3178-3186
作者:
Yang, Zhongduo
;
Song, Zhuwen
;
Xue, Weiwei
;
Sheng, Jie
;
Shu, Zongmei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/11/15
Aporphine alkaloids
Acetylcholinesterase inhibitors
Structure-activity relationships
Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 卷号: 94
作者:
Liu, Wei
;
Yang, Yadi
;
Cheng, Xuemei
;
Gong, Can
;
Li, Shuping
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Acetylcholinesterase
Butyrylcholinesterase
Acetylcholine
Inhibitor
UPLC-ESI MS/MS
Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
期刊论文
脑研究, 2014
Shao, Shuang
;
Li, Man
;
Du, Wei
;
Shao, Feng
;
Wang, Weiwen
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2015/11/10
Adolescence
MK-801
Social isolation
Galanthamine
Prepulse inhibition
MEDIAL PREFRONTAL CORTEX
LATENT INHIBITION
ADULT RATS
GLUTAMATERGIC-NMDA
NUCLEUS-ACCUMBENS
FEMALE RATS
SCHIZOPHRENIA
RECEPTORS
MEMORY
MICE
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease
期刊论文
European Journal of Medicinal Chemistry, 2014, 卷号: Vol.76, 页码: 314-331
作者:
Qiang, X.
;
Sang, Z.
;
Yuan, W.
;
Li, Y.
;
Liu, Q.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Aβ
aggregation
inhibitors
Acetylcholinesterase
inhibitors
Alzheimer's
disease
Genistein-O-alkylbenzylamines
Metal-chelating
Multifunctional
agents
Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase
期刊论文
European Journal of Medicinal Chemistry, 2014, 卷号: 74, 页码: 751-758
作者:
Wei, Yingling
;
Peng, Ai-Yun*
;
Wang, Bo
;
Ma, Lin
;
Peng, Guoping
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/23
Cholesterol esterase
Acetylcholinesterase
Inhibitor
Phosphorylated flavonoids
Organophosphate
Selectivity
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase
期刊论文
Bioorganic and Medicinal Chemistry, 2014, 卷号: 22, 期号: 17, 页码: 4784-4791
作者:
Sun, Qi
;
Peng, Da-Yong
;
Yang, Sheng-Gang
;
Zhu, Xiao-Lei
;
Yang, Wen-Chao*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
AD
Alzheimer’s disease
AChE
acetylcholinesterase
BChE
butylcholinesterase
ACh
acetylcholine
Aβ
amyloid-β
CAS
catalytic active site
PAS
peripheral active site
MD
molecular dynamics
ATC
acetylthiocholine
ESI-MS
electrospray ionisation mass spectrometry
DMF
dimethylformamide
DTNB
5′,5′-Dithio-bis(2-nitrobenzoic acid)
LGA
Lamarkian genetic algorithm
EDCI
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
HOBt
N-hydroxybenzotriazole
PyBOP
benzotriazole-1-yl-oxytripyrrolidino-phosphonium hexafluorophosphate
Alzheimer’s disease
Coumarin
Acetylcholinesterase inhibitor
Butylcholinesterase inhibitor
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