Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition   deficits induced by adolescent social isolation or MK-801 treatment

doi:10.1016/j.brainres.2014.09.032

CORC > 北京大学 > 心理与认知科学学院

	Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
	Shao, Shuang ; Li, Man ; Du, Wei ; Shao, Feng ; Wang, Weiwen
刊名	脑研究
	2014
关键词	Adolescence MK-801 Social isolation Galanthamine Prepulse inhibition MEDIAL PREFRONTAL CORTEX LATENT INHIBITION ADULT RATS GLUTAMATERGIC-NMDA NUCLEUS-ACCUMBENS FEMALE RATS SCHIZOPHRENIA RECEPTORS MEMORY MICE
DOI	10.1016/j.brainres.2014.09.032
英文摘要	Adolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders. Dysfunctions in the central cholinergic system are involved in creating the cognitive deficits observed in neurological diseases. In the present study, we aimed to investigate whether the acetylcholinesterase inhibitor galanthamine could reverse pre-cognitive prepulse inhibition (PPI) deficits and spatial learning deficits of adult rats in the Morris water maze. We induced these effects using either adolescent MK-801 treatment or social isolation from postnatal day (PND) 38-51. Our results showed that both adolescent social isolation and MK-801 treatment impaired PPI in adult rats, but neither had an effect on spatial learning. Furthermore, galanthamine injections over 7 days significantly enhanced PPI of normal rats and improved PPI disruption induced by adolescent pharmacological and rearing interventions. The results suggest that acetylcholinesterase inhibitors, such as galanthamine, might have the potential to improve pre-cognition in neurodevelopmental diseases by improving auditory sensory gating. (C) 2014 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345732600011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 1; ARTICLE; shaof@pku.edu.cn; wangww@psych.ac.cn; 105-111; 1589
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162730]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Shao, Shuang,Li, Man,Du, Wei,et al. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment[J]. 脑研究,2014.
APA	Shao, Shuang,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2014).Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment.脑研究.
MLA	Shao, Shuang,et al."Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment".脑研究 (2014).