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	Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase
	Sun, Qi; Peng, Da-Yong; Yang, Sheng-Gang; Zhu, Xiao-Lei; Yang, Wen-Chao*; Yang, Guang-Fu（杨光富）
刊名	Bioorganic and Medicinal Chemistry
	2014
卷号	22期号:17页码:4784-4791
关键词	AD Alzheimer’s disease AChE acetylcholinesterase BChE butylcholinesterase ACh acetylcholine Aβ amyloid-β CAS catalytic active site PAS peripheral active site MD molecular dynamics ATC acetylthiocholine ESI-MS electrospray ionisation mass spectrometry DMF dimethylformamide DTNB 5′,5′-Dithio-bis(2-nitrobenzoic acid) LGA Lamarkian genetic algorithm EDCI 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride HOBt N-hydroxybenzotriazole PyBOP benzotriazole-1-yl-oxytripyrrolidino-phosphonium hexafluorophosphate Alzheimer’s disease Coumarin Acetylcholinesterase inhibitor Butylcholinesterase inhibitor
ISSN号	0968-0896
DOI	10.1016/j.bmc.2014.06.057
URL标识	查看原文
WOS记录号	WOS:000341293300029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/5149119
专题	华中师范大学
作者单位	1.[Yang, Guang-Fu 2.Yang, Sheng-Gang 3.Zhu, Xiao-Lei 4.Yang, Wen-Chao 5.Sun, Qi 6.Peng, Da-Yong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
推荐引用方式 GB/T 7714	Sun, Qi,Peng, Da-Yong,Yang, Sheng-Gang,et al. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase[J]. Bioorganic and Medicinal Chemistry,2014,22(17):4784-4791.
APA	Sun, Qi,Peng, Da-Yong,Yang, Sheng-Gang,Zhu, Xiao-Lei,Yang, Wen-Chao*,&Yang, Guang-Fu.(2014).Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase.Bioorganic and Medicinal Chemistry,22(17),4784-4791.
MLA	Sun, Qi,et al."Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase".Bioorganic and Medicinal Chemistry 22.17(2014):4784-4791.

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