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Editorial: Applications of medicine in treating pulmonary fibrosis 期刊论文
FRONTIERS IN PHARMACOLOGY, 2023, 卷号: 14, 页码: 3
作者:  Li, Wenjun;  Shi, Xin;  Lv, Changjun;  Hu, Haibo;  Sundar, Isaac Kirubakaran
收藏  |  浏览/下载：1/0  |  提交时间：2024/01/26
Recent advances in stimuli-responsive polymeric micelles: Via click chemistry 期刊论文
Polymer Chemistry, 2019, 卷号: 10, 页码: 34-44
作者:  Dai, Yu;  Chen, Xin;  Zhang, Xiaojin
收藏  |  浏览/下载：72/0  |  提交时间：2019/11/19
Malignancy development risk in psoriatic arthritis patients undergoing treatment: A systematic review and meta-analysis 期刊论文
2019, 卷号: 48, 期号: 4, 页码: 626-631
作者:  Luo, Xuan;  Deng, Chuiwen;  Fei, Yunyun;  Zhang, Wen;  Li, Yongzhe
收藏  |  浏览/下载：8/0  |  提交时间：2020/01/03
Dynamics of synthetic drugs transmission model with psychological addicts and general incidence rate 期刊论文
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2018, 卷号: 491, 页码: 641-649
作者:  Ma, Mingju;  Liu, Sanyang;  Xiang, Hong;  Li, Jun
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/15
Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes. 期刊论文
Angewandte Chemie International Edition, 2017, 卷号: Vol.56 No.15, 页码: 4165-4169
作者:  Peng, JJ;  Samanta, A;  Zeng, X;  Han, SY;  Wang, L
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/31
Beneficial effects of Tai Chi for amphetamine-type stimulant dependence: a pilot study 期刊论文
The American journal of drug and alcohol abuse, 2016, 卷号: 42, 页码: 469-78
作者:  Zhu Dong[1];  Xu Ding[2];  Dai Guobin[3];  Wang Fei[4];  Xu Xin[5]
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/26
Research progress of polymer material carrier for protein and peptide drugs 期刊论文
Chinese Journal of Pharmaceutical Biotechnology, 2016, 卷号: 23, 期号: 5, 页码: 417-421
作者:  Ding T.-T.;  Fan Y.;  Lin G.-M.
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/16
Risk control and rational recreation: A qualitative analysis of synthetic drug use among young urbanites in China 期刊论文
INTERNATIONAL JOURNAL OF DRUG POLICY, 2014, 卷号: 25, 页码: 769-775
作者:  Lin, Shaozhen[1];  Zhang, Yong-an[2]
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/30
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
复方药物研发创新体系展望 期刊论文
2010, 2010
罗国安; 梁琼麟; 刘清飞; 李雪; 王义明; Luo Guoan; Liang Qionglin; Wang Yiming; Liu Qingfei; Li Xue
收藏  |  浏览/下载：7/0

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