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IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation 期刊论文
2019, 卷号: 212, 页码: 36-53
作者:  Ai Q D;  Chen Chen;  Chu Shifeng;  Zhang Zhao;  Luo Yun
收藏  |  浏览/下载:26/0  |  提交时间:2020/01/03
ASC = apoptosis-associated speck-like protein containing a caspase activation recruitment domain  BCA = bicinchoninic acid  BSA = bovine serum albumin  CCA = common carotid artery  CCR4 = C-C chemokine receptor type 4  CKLF1 = chemokine-like factor 1  CO-IP = coimmunoprecipitation  ECA = external carotid artery  ELISA = enzyme-linked immunosorbent assay  FDA = Food and Drug Administration  I/R = ischemic/reperfusion  ICA = internal carotid artery  IL-18 = interleukin 18  IL-1β = interleukin 1β  LDH = lactate dehydrogenase  NLRP3 = NOD-like receptor protein 3  PBS = phosphate-buffered saline  SD = standard deviation  TNF-α = tumor necrosis factor α  TTC = 2  3  5-triphenyltetrazolium-chloride  WT = wild-type  pMCAO = permanent middle cerebral artery occlusion  pro-Caspase-1 = precursor Caspase-1  qPCR = quantitative real-time PCR  tMCAO = transient middle cerebral artery occlusion  tPA = tissue plasminogen activator  
Effect of galectin-3 on vasculogenic mimicry in esophageal cancer cells 期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 15, 期号: 4, 页码: 4907-4911
作者:  Zhang, Jingxin;  Deng, Guodong;  Qiao, Lili;  Luo, Hui;  Liu, Qiqi
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/11
Myelin injury in the central nervous system and Alzheimer's disease 期刊论文
Brain Research Bulletin, 2018, 卷号: 140, 页码: 162-168
作者:  Wang, Sha-Sha;  Zhang, Zhao;  Zhu, Tian-Bi;  Chu, Shi-Feng;  He, Wen-Bin
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/27
OLG  oligodendrocyte  CNS  central nervous system  SC  Schwann cell  PNS  peripheral nervous system  MBP  myelin basic protein  PLP  proteolipid protein  P0/MPZ  myelin protein zero  EAE  experimental allergic encephalomyelitis  MS  multiple sclerosis  CNP  2′ 3′-cyclic nucleotide 3′-phosphodiesterase  MAG  myelin associated glycoprotein  MOG  myelin oligodendrocyte glycoprotein  AD  Alzheimer's disease  OPC  oligodendrocyte precursor cell  NPC  neural progenitor cell  ROS  reactive oxygen species  TNF  tumour necrosis factor  AIF  apoptosis-inducing factor  IFN-γ  interferon gamma  ERK1/2  extracellular signal-regulated kinases-1 and -2  MAPK  mediators of mitogen-activated protein kinase  FGFR1/2  fibroblast growth factor receptors-1 and -2  Dock3  dedicator of cytokinesis 3  PERK  pancreatic endoplasmic reticulum kinase  GEF  guanine nucleotide exchange factor  SIRT2  sirtuin 2  NOD2  Nucleotide-binding oligomerization domain containing protein 2  RIPK2  receptor-interacting serine/threonine kinase 2  Shh  Sonic Hedgehog  NMO  neuromyelitis optica  ADEM  acute disseminated encephalomyelitis  ANHLE  acute necrotizing hemorrhagic leukoencephalitis  CPM  central pontine myelinolysis    beta-amyloid  SP  senile plaque  NFT  neurofibrillary tangle  MRI  magnetic resonance imaging  Myelin  Oligodendrocyte  Demyelination  Neurodegenerative diseases  Alzheimer’s disease  
Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain. 期刊论文
Neural regeneration research, 2017, 卷号: 12, 期号: 11
作者:  ;  Li Heng-Xi;  ;  Wu Hai-Ying;  Zhu Lie
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/04
Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain 期刊论文
NEURAL REGENERATION RESEARCH, 2017, 卷号: 12, 页码: 1843-1852
作者:  Li, Ping;  Li, Heng-xi;  Jiang, Hong-yan;  Zhu, Lie;  Wu, Hai-ying
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells 期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:  Wang, Jing;  Yang, Xin;  Zhang, Jingjing*
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/03
4E-BP1  4E binding protein  AMPK  AMP-activated protein kinase  ATF6  activating transcription factor 6  ATP  adenosine triphosphate  DEPTOR  DEP domain containing mTOR-interacting protein  CI  complexes I  CII  complex II  CIII  complex III  CIV  complex IV  CV  complex V  eIF2α  Eukaryotic Initiation Factor 2α  ER  Endoplasmic Reticulum  ERAD  ER-associated degradation  ERO1α  ER oxidoreductase 1 α  FoxO1  Forkhead box O1  GβL  G Protein β Subunit Like Protein  GRP78  78 kDa glucose-regulated protein precursor  GSIS  glucose-stimulated insulin secretion  IRE1  Inositol-requiring enzyme 1  IRS1  Insulin receptor substrate 1  IRS2  Insulin receptor substrate 2  mLST8  mammalian lethal with sec-13 protein 8  mSin1  the mammalian stress-activated MAP kinase-interaction protein 1  mtDNA  mitochondrial deoxyribonucleic acid  mTOR  mammalian TOR  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  NADPH oxidase  Nicotinamide adenine dinucleotide phosphate-oxidase  NOS  nitric oxide synthase  O2–·  superoxide anion  H2O2  hydrogen peroxide  OH·  hydroxyl radical  3O2  triplet-state molecular oxygen  OXPHOS  oxidative phosphorylation  CAT  catalase  GPx  glutathioneperoxidase  PERK  Protein kinase R-like endoplasmic reticulum kinase  PDI  ER protein disulfide isomerases  PI3K  the phosphoinositide3-kinase  PRAS40  40-kDa proline-rich Akt substrate  PRAS40  the 40-kDa proline-rich Akt substrate  PROTOR  the protein observed with RICTOR  RAPTOR  regulatory-associated protein of mTOR  RICTOR  The rapamycin-insensitive companion of mTOR  REDD1  DNA damage response 1  RNS  reactive nitrogen species  ROS  reactive oxygen species  RNS  reactive nitrogen species  S6K  S6 kinase  SOD  superoxidedismutase  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TOR  the target of rapamycin  TSC2  Tuberous sclerosis 2  UPR  unfolded protein response  Mitochondrial oxidative stress  ER stress  mTOR  Pancreatic β cells  
Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease 期刊论文
AGING-US, 2016
Zhang, Chi; Lu, Jie; Liu, Bing; Cui, Qinghua; Wang, Yun
收藏  |  浏览/下载:6/0  |  提交时间:2017/12/03
Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats 期刊论文
journal of alzheimers disease, 2010
Cheng, Yong; Yu, Long-Chuan
收藏  |  浏览/下载:2/0  |  提交时间:2015/11/14
Receptor-associated Protein Interacts with Amyloid-beta Peptide and Promotes Its Cellular Uptake 期刊论文
http://dx.doi.org/10.1074/jbc.M109.015032, 2009
Kanekiyo, Takahisa; Bu, Guojun; 卜国军
收藏  |  浏览/下载:2/0  |  提交时间:2015/07/22


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