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复旦大学上海医学院 [5]
武汉大学 [3]
广州生物医药与健康研... [2]
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期刊论文 [13]
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Oncology [2]
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OTUB1 protein suppresses mTOR complex 1 activity by deubiquitinating the mTORC1 inhibitor DEPTOR
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: Vol.293 No.13, 页码: 4883-4892
作者:
Zhao, LL
;
Wang, XB
;
Yu, Y
;
Deng, L
;
Chen, L
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/26
cancer
biology
cell
signaling
deubiquitylation
(deubiquitination)
protein
stability
tumor
cell
biology
DEPTOR
OTU
domain-containing
ubiquitin
aldehyde-binding
protein
1
(OTUB1)
mTORC1
DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia
期刊论文
ONCOGENE, 2017, 卷号: 36, 期号: 8
作者:
Hu, Y.
;
Su, H.
;
Liu, C.
;
Wang, Z.
;
Huang, L.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Reciprocal Negative Regulation between EGFR and DEPTOR Plays an Important Role in the Progression of Lung Adenocarcinoma
期刊论文
MOLECULAR CANCER RESEARCH, 2016, 卷号: 14, 期号: 5
作者:
Zhou, Xuefeng
;
Guo, Jialong
;
Ji, Yanmei
;
Pan, Gaofeng
;
Liu, Tao
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 12
作者:
Ji, Yan-Mei
;
Zhou, Xue-Feng
;
Zhang, Jun
;
Zheng, Xiang
;
Li, Sheng-Bao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
DEPTOR
mTOR
esophageal squamous cell carcinoma
proliferation
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway
期刊论文
AUTOPHAGY, 2015
Wei, Fu-Zheng
;
Cao, Ziyang
;
Wang, Xi
;
Wang, Hui
;
Cai, Mu-Yan
;
Li, Tingting
;
Hattori, Naoko
;
Wang, Donglai
;
Du, Yipeng
;
Song, Boyan
;
Cao, Lin-Lin
;
Shen, Changchun
;
Wang, Lina
;
Wang, Haiying
;
Yang, Yang
;
Xie, Dan
;
Wang, Fan
;
Ushijima, Toshikazu
;
Zhao, Ying
;
Zhu, Wei-Guo
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
autophagy
EZH2
histone modification
MTA2
MTOR pathway
EMBRYONIC STEM-CELLS
CHROMATIN-REMODELING COMPLEX
HISTONE DEACETYLASE
DNA-DAMAGE
MI-2/NURD COMPLEX
TUMOR-SUPPRESSOR
FACTOR CHD4
IN-VIVO
NURD
METHYLATION
DEPTOR is a direct NOTCH1 target that regulates proliferation, metabolism and glucocorticoid resistance in T cell leukemia
期刊论文
CANCER RESEARCH, 2015, 卷号: 75
Hu, Yufeng
;
Su, Hexiu
;
Ye, Qi
;
Wang, Zhaojing
;
Huang, Liang
;
Wang, Qian
;
Liu, Shuangyou
;
Chen, Suning
;
Zhou, Jianfeng
;
Li, Peng
;
Qing, Guoliang
;
Liu, Hudan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2016/12/16
DEPTOR is a direct NOTCH1 target that regulates proliferation, metabolism and glucocorticoid resistance in T cell leukemia
期刊论文
CANCER RESEARCH, 2015, 卷号: 75
作者:
Ye, Qi
;
Huang, Liang
;
Wang, Qian
;
Liu, Shuangyou
;
Chen, Suning
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2018/12/13
DEPTOR Expression Negatively Correlates with mTORC1 Activity and Tumor Progression in Colorectal Cancer
期刊论文
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 卷号: 15, 期号: 11
作者:
Lai, Er-Yong
;
Chen, Zhen-Guo
;
Zhou, Xuan
;
Fan, Xiao-Rong
;
Wang, Hua
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/04
Colorectal cancer
mTOR
DEPTOR
P-S6
immunohistochemistry
Induction of Protective Autophagy in Cancer Cells by NAE Inhibitor MLN4924
图书章节
2014
作者:
Jiang, Yanan/56939172000[0]
;
Jia, Lijun/26653512000[1]
;
Sun, Yi/55520058800[2]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
Anticancer therapy
Autophagy in tumorigenesis
DEPTOR
MLN4924-induced autophagy
Neddylation
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