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浏览/检索结果: 共5条，第1-5条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030 作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li 收藏  |  浏览/下载：111/0  |  提交时间：2021/05/24 Morphinans  arylacetamidyl substituent  kappa opioid receptor modulators  structure-activity relationships   Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070 作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui 收藏  |  浏览/下载：92/0  |  提交时间：2020/07/01 Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non‐medullary thyroid carcinoma 期刊论文 International Journal of Cancer, 2019, 卷号: Vol.144 No.6, 页码: 1321-1330 作者:  Feng Ye;  Hongwei Gao;  Lin Xiao;  Zhixiang Zuo;  Yueping Liu 收藏  |  浏览/下载：20/0  |  提交时间：2019/12/13 Familial  medullary  thyroid  carcinoma  familial  non‐medullary  thyroid  carcinoma  MAP2K5‐ERK5  signaling  MAP2K1/2‐ERK1/2  signaling   Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12 作者:  Xu, Yulong;  Yang, Xicheng;  Chen, Yiyi;  Chen, Hao;  Sun, Huijiao 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05 Proteasome inhibitors  Topology-based  Scaffold hopping  Bortezomib   Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands 期刊论文 中国药理学报, 2017, 卷号: 38, 期号: 1 作者:  Shen Jian;  Yang Xicheng;  Yu Mingcheng;  Xiao Li;  Zhang Xunjie 收藏  |  浏览/下载：10/0  |  提交时间：2019/12/05 a7 nAChR  acetylcholine-binding protein ligands  piperidine derivatives  molecular modeling  psychotic disorders