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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：99/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer 期刊论文 CELL DEATH & DISEASE, 2018, 卷号: 9 作者:  Mao, Jianhua;  Ma, Lie;  Shen, Yan;  Zhu, Kongkai;  Zhang, Ru 收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08 Current Strategies and Applications for Precision Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Wang, Chen;  Xu, Pan;  Zhang, Luyu;  Huang, Jing;  Zhu, Kongkai 收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08 precision medicine  precision drug design  computational modeling  deep learning  antibody-drug conjugates  ligand-targeted conjugates   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Current Strategies and Applications for Precision Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Wang, Chen;  Xu, Pan;  Zhang, Luyu;  Huang, Jing;  Zhu, Kongkai 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05 precision medicine  precision drug design  computational modeling  deep learning  antibody-drug conjugates  ligand-targeted conjugates   Phenolic bisabolane sesquiterpenoids from a Thai mangrove endophytic fungus, Aspergillus sp xy02 期刊论文 2018, 卷号: 127, 页码: 322 作者:  Wang, Pan[1];  Yu, Jin-Hai[2];  Zhu, Kongkai[2];  Wang, Yinyin[2];  Cheng, Zhi-Qiang[2] 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/06 Total synthesis, structural revision and biological evaluation of γ-elemene-type sesquiterpenes 期刊论文 Organic & Biomolecular Chemistry, 2018, 卷号: Vol.16 No.42, 页码: 7843-7850 作者:  Changchun Yuan;  Shangyong Zhong;  Xingyi Li;  Yanhong Wang;  Miao-Miao Xun 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/26 Phenolic bisabolane sesquiterpenoids from a Thai mangrove endophytic fungus, Aspergillus sp xy02 期刊论文 2018, 卷号: 127, 页码: 322-327 作者:  Wang, Pan;  Yu, Jin-Hai;  Zhu, Kongkai;  Wang, Yinyin;  Cheng, Zhi-Qiang 收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03 Mangrove  Endophytic fungus  Aspergillus  Bisabolane sesquiterpenoids  Antibacterial activity   Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者:  Zhu, Kongkai;  Jiang, Cheng-Shi;  Hu, Junchi;  Liu, Xigong;  Yan, Xue 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PRMT5 SAM competitive inhibitor  Molecular docking  Molecular dynamics simulation  Molecular mechanics/Poisson-Boltzmann surface area  PRMT5:MEP50 interaction