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科研机构
上海药物研究所 [12]
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期刊论文 [12]
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2021 [5]
2020 [1]
2019 [2]
2018 [1]
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PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery
期刊论文
AUTOPHAGY, 2021, 卷号: 17, 期号: 10, 页码: 2905-2922
作者:
Tang, Ying
;
Liu, Jinchang
;
Wang, Yu
;
Yang, Li
;
Han, Bing
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/04
Autophagy
functional recovery
ischemic stroke
lysophosphatidic acid receptor 5
microglial activation
poly (ADP-ribose) polymerase 14
Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats
期刊论文
NEUROREPORT, 2021, 卷号: 32, 期号: 13, 页码: 1140-1146
作者:
Fu, Yao
;
Xing, Rongrong
;
Wang, Linlin
;
Yang, Li
;
Jiang, Baohong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/11/04
acute ischemic stroke
ginsenoside Rg1
salvianolic acid B
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
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  |  
浏览/下载:85/0
  |  
提交时间:2021/11/04
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
收藏
  |  
浏览/下载:110/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 12, 页码: 6523-6537
作者:
Zhao, Jihui
;
Cui, Rongrong
;
Wang, Lihao
;
Chen, Yingjia
;
Fu, Zunyun
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2020/07/01
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:
Wang, Yulan
;
Dai, Yang
;
Wu, Xiaowei
;
Li, Fei
;
Liu, Bo
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 17, 页码: 3486-3503
作者:
Dong, Jiajia
;
Olaleye, Olajide E.
;
Jiang, Rongrong
;
Li, Jing
;
Lu, Chuang
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 5, 页码: 669-678
作者:
Jia, Weiwei
;
Du, Feifei
;
Liu, Xinwei
;
Jiang, Rongrong
;
Xu, Fang
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
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