Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats

doi:10.1097/WNR.0000000000001706

	Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats
	Fu, Yao 1,2; Xing, Rongrong 1; Wang, Linlin 1; Yang, Li 2; Jiang, Baohong 1
刊名	NEUROREPORT
	2021-09-08
卷号	32 期号:13 页码:1140-1146
关键词	acute ischemic stroke ginsenoside Rg1 salvianolic acid B
ISSN号	0959-4965
DOI	10.1097/WNR.0000000000001706
通讯作者	Yang, Li(yangli2017@dlut.edu.cn)
英文摘要	Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). SalB-Rg1 decreased infarct area through 3,5-triphenyltetrazolium chloride stain and improved neurological behavior through Longa Score or Left-Biased Swings on both MCAO rats and CI/R rats. Neural protection of SalB-Rg1 against ischemia or ischemic reperfusion injury was evidenced by the inhibition of nucleus pyknosis, liquefaction necrosis through H&E stain and Nissl stain. Furthermore, protection of SalB-Rg1 on blood-brain barrier (BBB) was more significant on CI/R rats, accompanying with the downregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, and recovery of zonula occludens-1 expression. These results provide compelling evidence that SalB-Rg1 holds the potential to be developed as an optimal therapeutic strategy to alleviate the injury of ischemia or ischemic reperfusion.
资助项目	Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008] ; Shanghai Science and Technology Development Foundation[21S21901900] ; National Natural Science Foundation of China[81770478]
WOS关键词	MYOCARDIAL-INFARCTION ; BRAIN
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000683520200010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298098]
专题	中国科学院上海药物研究所
通讯作者	Yang, Li
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yao,Xing, Rongrong,Wang, Linlin,et al. Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats[J]. NEUROREPORT,2021,32(13):1140-1146.
APA	Fu, Yao,Xing, Rongrong,Wang, Linlin,Yang, Li,&Jiang, Baohong.(2021).Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats.NEUROREPORT,32(13),1140-1146.
MLA	Fu, Yao,et al."Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats".NEUROREPORT 32.13(2021):1140-1146.