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科研机构
上海药物研究所 [32]
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期刊论文 [32]
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2021 [3]
2019 [4]
2018 [8]
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Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 页码: 6
作者:
Fan, Min
;
Wang, Ting
;
Peng, Li-Yan
;
Huang, Jun-Shang
;
Wu, Xing-De
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/11/04
Salvia hispanica
neo-clerodane diterpenoid
salvihispin H
type 2 diabetes mellitus
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 43, 页码: 21732-21738
作者:
Liu, Bin
;
Zhang, Zhijian
;
Hu, Yanyun
;
Lu, Yan
;
Li, Duanzhuo
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2020/07/01
type 2 diabetes
gluconeogenesis
hepatic glucose production
ER stress
USP14
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 5, 页码: 2348-2361
作者:
Li, Shiliang
;
Qin, Chun
;
Cui, Shichao
;
Xu, Hongling
;
Wu, Fangshu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia
期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 卷号: 45, 期号: 12, 页码: 1257-1264
作者:
Zhou, Tingting
;
Du, Mengfan
;
Zhao, Tong
;
Quan, Lingling
;
Zhu, Zhiyuan
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2019/01/08
beta cell
apoptosis
glucose-stimulated insulin secretion
T2DM
Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2018, 卷号: 9
作者:
Tang, Dan
;
Liu, Liu
;
Ajiakber, Dildar
;
Ye, Jianping
;
Xu, Jianjun
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
type 2 diabetes mellitus
Punica granatum L. flower
anti-diabetic herb
oral glucose tolerance test
endoplasmic reticulum stress
insulin resistance
SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2018, 卷号: 315, 期号: 2, 页码: E294-E306
作者:
Wang, Junlong
;
Xu, Shimeng
;
Gao, Jing
;
Zhang, Linqiang
;
Zhang, Zhiguo
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2019/01/08
liver
rhesus monkey
stable isotope labeling with amino acids in cell culture-based quantitative proteomics
spontaneous Type 2 diabetes
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