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科研机构
上海药物研究所 [68]
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期刊论文 [68]
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2021 [10]
2020 [8]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 379, 期号: 2, 页码: 125-133
作者:
Han, Li
;
Ma, Chenhui
;
Peng, Huige
;
Wu, Zhitao
;
Xu, Huiming
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/04
Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury
期刊论文
FASEB JOURNAL, 2021, 卷号: 35, 期号: 11, 页码: 17
作者:
Wu, Yong-Mei
;
Shi, Qing
;
Zhu, Peng-Fei
;
Ma, Hai-Jian
;
Cui, Shi-Chao
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/12/16
acute kidney injury
IKK/NF-kappa B
inflammation
macrophage
PI3K/PDK1/Akt
rhodomeroterpene
Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction
期刊论文
PHYTOMEDICINE, 2021, 卷号: 90, 页码: 12
作者:
Zhi, Haijuan
;
Zhang, Zijia
;
Deng, Yanping
;
Yan, Bingpeng
;
Li, Zhenwei
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/11/04
Acute myocardial infarction
Danqi Tongmai tablet
In vivo metabolite
Oxylipin
Arachidonic acid metabolome
Homeostasis
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11
作者:
Bao, Weilian
;
Liu, Xiaohong
;
You, Yan
;
Hou, Hui
;
Wang, Xu
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/11/16
SNX10
IBD
Macrophage
PIKfyve
TBK1
PPI inhibitor
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 6
作者:
Xiong, Fengmin
;
Ding, Xiaoyu
;
Zhang, Hao
;
Luo, Xiaomin
;
Chen, Kaixian
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/08/17
Monoacylglycerol lipase
Inhibitor
Virtual screening
Inflammation
NOD-like receptors in autoimmune diseases
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 15
作者:
Chen, Li
;
Cao, Shi-qi
;
Lin, Ze-min
;
He, Shi-jun
;
Zuo, Jian-ping
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
pattern recognition receptors
NOD-like receptors
autoimmune diseases
inflammasomes
inhibitors
botanicals
Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 265, 页码: 12
作者:
Lin, Ze-min
;
Liu, Yu-ting
;
Huang, Yue-teng
;
Yang, Xiao-qian
;
Zhu, Feng-hua
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Periploca sepium Bunge
Pregnane glycosides
Anti-nociceptive activity
Anti-inflammatory activity
Anti-arthritic activity
Inflammatory arthritis
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