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上海药物研究所 [15]
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期刊论文 [100]
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Pressure-Regulated Gene Expression and Enzymatic Activity of the Two Periplasmic Nitrate Reductases in the Deep-Sea Bacterium Shewanella piezotolerans WP3
研究报告
2018
作者:
Qi XQ
;
Li XG(李学恭)
;
Zhang WJ
;
Xiao X
;
Jian HH
收藏
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浏览/下载:56/0
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提交时间:2019/01/09
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
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  |  
浏览/下载:234/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
期刊论文
European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689
作者:
Wang, Qi
;
Dai, Yang
;
Ji, Yinchun
;
Shi, Huanyu
;
Guo, Zuhao
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浏览/下载:85/0
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提交时间:2019/01/08
Alterations of early-stage decomposition of leaves and absorptive roots by deposition of nitrogen and phosphorus have contrasting mechanisms
期刊论文
SOIL BIOLOGY & BIOCHEMISTRY, 2018, 卷号: 127, 页码: 213-222
作者:
Jiang, Lei
;
Kou, Liang
;
Li, Shenggong
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浏览/下载:36/0
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提交时间:2019/05/23
Litter decomposition
Nutrient deposition
AUR
Phosphorus limitation
Nitrogen addition
Microbial enzymatic activity
Beyond the Roles in Biomimetic Chemistry: An Insight into the Intrinsic Catalytic Activity of an Enzyme for Tumor-Selective Phototheranostics
期刊论文
ACS NANO, 2018, 卷号: 12, 期号: 12, 页码: 12169-12180
作者:
Zhang, Bingbo
;
Zhou, Xin
;
Chen, Shizhen
;
Yao, Defan
;
Shi, Yuxin
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  |  
浏览/下载:43/0
  |  
提交时间:2019/06/24
biomimetic synthesis
protein activity
catalytic nanomedicine
MR/PA imaging
photothermal therapy
Graphene enhanced transformation of lignin in laccase-ABTS system by accelerating electron transfer
期刊论文
ENZYME AND MICROBIAL TECHNOLOGY, 2018, 卷号: 119, 页码: 17-23
作者:
Pan, Yu
;
Ma, Hua
;
Huang, Liping
;
Huang, Juan
;
Liu, Yan
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浏览/下载:39/0
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提交时间:2018/11/12
Lignin Degradation
Laccase
Abts
Graphene
Electron Transfer
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:
Zhu, Kongkai
;
Tao, Hongrui
;
Song, Jia-Li
;
Jin, Lu
;
Zhang, Yuanyuan
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  |  
浏览/下载:129/0
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提交时间:2019/01/08
PRMT5 inhibitor
Arginine methylation
Virtual screening
Molecular docking
Molecular dynamics simulation
Bt rice cultivation does not cause soil biological degradation in terms of C, N, and P cycles
期刊论文
LAND DEGRADATION & DEVELOPMENT, 2018, 卷号: 29, 期号: 11, 页码: 4140-4145
作者:
Li, Zhaolei
;
Wang, Bingxue
;
Tian, Dashuan
;
Wang, Jinsong
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浏览/下载:87/0
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提交时间:2019/05/23
Bt rice
cultivation
ecosystem processes
enzymatic activities
nutrients
Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors
期刊论文
Chemical biology & drug design, 2018
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Song, Kun
;
Ruan, Cong
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  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine
期刊论文
SENSORS AND ACTUATORS B-CHEMICAL, 2018, 卷号: 270, 页码: 443-451
作者:
Wu, Yehui
;
Chen, Yuzhi
;
Li, Yawen
;
Huang, Jia
;
Yu, Hao
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  |  
浏览/下载:36/0
  |  
提交时间:2019/04/09
Nanozyme
Gold Nanoparticle
Peroxidase
Purine
Red Blood Cell
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