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上海药物研究所 [189]
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期刊论文 [188]
会议论文 [1]
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A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles
期刊论文
BIOCONJUGATE CHEMISTRY, 2021, 卷号: 32, 期号: 11, 页码: 2290-2294
作者:
Qi, Jingjing
;
Liu, Sixiu
;
Seydimemet, Mengnisa
;
Wang, Xuan
;
Lu, Xiaojie
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/04
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640
作者:
Zhang, Shiyan
;
Lou, Jianfeng
;
Li, Yafang
;
Zhou, Feilong
;
Yan, Ziqin
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
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  |  
浏览/下载:83/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2021, 页码: 11
作者:
Xiong, Zhaoping
;
Cheng, Ziqiang
;
Lin, Xinyuan
;
Xu, Chi
;
Liu, Xiaohong
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
federated learning
drug discovery
FedAMP
Non-IID data
Identification of novel anti-inflammatory Nur77 modulators by virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7
作者:
Ding, Xiaoyu
;
Zhao, Zijie
;
Wu, Yue
;
Zhang, Hao
;
Chen, Kaixian
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/08/17
Nur77
Binding site evaluation
Virtual Screening
Inflammation
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation
期刊论文
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021, 页码: 15
作者:
Chen, Li
;
Zhao, Shuang
;
Zhu, Yanyan
;
Liu, Yongsheng
;
Li, Huiyu
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  |  
浏览/下载:26/0
  |  
提交时间:2021/08/17
STING
Small molecule
Binding site
Modulated mechanism
Molecular dynamics simulation
pi-pi stacking interaction
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix
期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2021, 卷号: 464, 页码: 8
作者:
Xu, Yang
;
Deng, Yingzhi
;
Ye, Rongrong
;
Gong, Can
;
Liu, Zhaoxin
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/06/11
Single-layer graphene oxide film
Matrix-assisted laser desorption ionization-mass spectrometry imaging
Phospholipids
Pre-coated matrix
Pharmacological inhibition of NF-kappa B-inducing kinase (NIK) with small molecules for the treatment of human diseases
期刊论文
RSC MEDICINAL CHEMISTRY, 2021, 卷号: 12, 期号: 4, 页码: 552-565
作者:
Cheng, Jing
;
Feng, Xuexin
;
Li, Zhiqiang
;
Zhou, Feilong
;
Yang, Jin-Ming
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2021/08/17
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