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科研机构
上海药物研究所 [20]
上海中医药大学 [3]
中国科学院大学 [2]
大连化学物理研究所 [1]
复旦大学上海医学院 [1]
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期刊论文 [27]
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2021 [2]
2019 [6]
2018 [2]
2017 [1]
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Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 5, 页码: 17
作者:
Koronowski, Kevin B.
;
Greco, Carolina M.
;
Huang, He
;
Kim, Jin-Kwang
;
Fribourgh, Jennifer L.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/11/04
DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 91, 页码: 12
作者:
Chen, Li
;
Lin, Zemin
;
Liu, Yuting
;
Cao, Shiqi
;
Huang, Yueteng
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
DZ2002
Psoriasis
DNA methylation
Keratinocyte
Inflammatory infiltration
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 期号: 1, 页码: 15
作者:
Zhang, Zongwang
;
Wu, Yanwei
;
Wu, Bing
;
Qi, Qing
;
Li, Heng
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Systemic sclerosis
SAHH inhibitor
Fibrosis
Inflammation
Vasculopathy
TGF-beta
Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2019, 卷号: 9, 期号: 1, 页码: 25-33
作者:
Jia, Weiwei
;
Li, Jing
;
Du, Feifei
;
Sun, Yan
;
Xu, Fang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
S-adenosyl-L-homocysteine hydrolase
DZ2002
Carboxylesterases
Pharmacokinetics
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal -actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 页码: 16
作者:
He, Shijun
;
Liu, Xing
;
Lin, Zemin
;
Liu, Yuting
;
Gu, Lei
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
Arthritis Research & Therapy, 2019, 卷号: 21, 期号: 1
作者:
He,Shijun
;
Liu,Xing
;
Lin,Zemin
;
Liu,Yuting
;
Gu,Lei
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
α-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2019, 卷号: 9, 期号: 1
作者:
Li, Chuan
;
Olaleye, Olajide E.
;
Chen, Danghui
;
Tang, Wei
;
Zuo, Jianping
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/05
S-adenosyl-L-homocysteine hydrolase
DZ2002
Carboxylesterases
Pharmacokinetics
assaydevelopmentfordeterminationofdz2002anewreversiblesahhinhibitoranditsacidmetabolitedzainbloodandapplicationtoratpharmacokineticstudy
期刊论文
药物分析学报英文版, 2019, 卷号: 009, 期号: 001, 页码: 25
作者:
Weiwei Jia
;
Jing Li
;
Feifei Du
;
Yan Sun
;
Fang Xu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
S-adenosyl-L-homocysteine
hydrolase
DZ2002
Carboxylesterases
Pharmacokinetics
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-alpha/IFN-gamma-induced inflammatory response in keratinocytes and T cell-derived IL-17
期刊论文
PHARMACOLOGICAL RESEARCH, 2018, 卷号: 129, 页码: 443-452
作者:
Lin, Ze-Min
;
Ma, Meng
;
Li, Heng
;
Qi, Qing
;
Liu, Yu-Ting
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Reversible S-adenosyl-L-homocysteine
hydrolase inhibitor
Keratinocyte
Inflammation
Interleukin-17
Imiquimod
Psoriasis
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-alpha/IFN-gamma-induced inflammatory response in keratinocytes and T cell-derived IL-17
期刊论文
PHARMACOLOGICAL RESEARCH, 2018, 卷号: 129
作者:
Lin, Ze-Min
;
Ma, Meng
;
Li, Heng
;
Qi, Qing
;
Liu, Yu-Ting
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Reversible S-adenosyl-L-homocysteine
hydrolase inhibitor
Keratinocyte
Inflammation
Interleukin-17
Imiquimod
Psoriasis
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