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科研机构
中南大学 [7]
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期刊论文 [7]
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2017 [1]
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Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms
期刊论文
Cancer Treatment Reviews, 2017, 卷号: 54, 页码: 24-33
作者:
Peng, Mei*
;
Darko, Kwame Oteng
;
Tao, Ting
;
Huang, Yanjun
;
Su, Qiongli
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/03
AIs
aromatase inhibitors
AMPK
Adenosine Monophosphate-Activated Protein Kinase
AR
androgen
ATM
Ataxia Telangiectasia Mutated
ATP
Adenosine Triphosphate
BCSS
breast cancer specific survival
CK-MB
Creatine Kinase-MB
CREB1
cAMP Response Element-Binding Protein 1
CSC
cancer stem cell
DFS
disease-free survival
DHFU
dihydrofluorouracil
DPD
dihydropyrimidine dehydrogenase
EpCAM
Epithelial Cell Adhesion Molecule
ER
estrogen
ERCC1
excision repair cross-complementary 1
ERK
extracellular signal-regulated kinases
EZH2
enhancer of zeste homolog 2
FdUMP
fluorodeoxyuridine monophosphate
FdUTP
fluorodeoxyuridine triphosphate
FHC
ferritin heavy chain
FUTP
fluorouridine triphosphate
HbA1C
hemoglobin A1c
HER
Human Epidermal Growth Factor Receptor
HIF-1α
hypoxia-inducible factor-1α
HK
hexokinase
IGF1R
insulin growth factor 1 receptor
LDH
lactate dehydrogenase
MDA
Muscular Dystrophy Association
MMP
Matrix Metallopeptidase
MRP1
multidrug resistance-associated protein 1
mTOR
mammalian target of rapamycin
MTX
methotrexate
NCCN
National Comprehensive Cancer Network
OS
overall survival
pCR
Pathologic Complete Response
PDGFR
platelet-derived growth factor receptors
PFS
progression-free survival
PKA
protein kinase A
PR
progesterone receptor
RFS
relapse-free survival
SOD
superoxide dismutase
TAM
tamoxifen
TCA
tricarboxlic acid
TS
thymidylate synthase
Combination
Mechanisms
Metformin
Chemotherapeutic drugs
MiR-135a and MRP1 play pivotal roles in the selective lethality of phenethyl isothiocyanate to malignant glioma cells
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2016, 卷号: 6, 期号: 5, 页码: 957-972
作者:
Zhang, Taolan
;
Shao, Yingying
;
Chu, Tang-Yuan
;
Huang, Hsuan-Shun
;
Liou, Yu-Ligh
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/03
MRP1
Phenethyl isothiocyanate
glioma
miR-135a
selective lethality
MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma
期刊论文
Cancer Cell International, 2013, 卷号: 13, 期号: 1, 页码: 3
作者:
Lin, Shibo
;
Hoffmann, Katrin
;
Xiao, Zhi
;
Jin, Nan
;
Galli, Uwe
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Hepatocellular carcinoma
MEK
MRP1
MRP3
Multidrug resistance
Nilotinib (AMN107, Tasigna®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
期刊论文
Biochemical Pharmacology, 2009, 卷号: 78, 期号: 2, 页码: 153-161
作者:
Tiwari, Amit K.
;
Sodani, Kamlesh
;
Wang, Si-Rong
;
Kuang, Ye-Hong
;
Ashby, Charles R., Jr.
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
ABCB1 (P-gp)
P-glycoprotein
ABCG2
also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein)
ABCC1 (MRP1)
multidrug resistance protein 1
EGFR
epidermal growth factor receptor
HER
human epidermal receptor
TKI
tyrosine kinase inhibitor
PBS
phosphate-buffered saline
FTC
fumitremorgin C
E217βG
estradiol 17-β-d-glucuronide
d
MX
mitoxantrone
MTX
methotrexate
Nilotinib
ABC transporters
ABCB1
ABCG2
BCR-Abl
Tyrosine kinase inhibitor
Multidrug resistance
Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population
期刊论文
PHARMACOGENETICS AND GENOMICS, 2009, 卷号: 19, 期号: 3, 页码: 206-216
作者:
Yin, Ji-Ye
;
Huang, Qiong
;
Yang, Youyun
;
Zhang, Jian-Ting
;
Zhong, Mei-Zuo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Atp-binding cassette transporter
Drug resistance
Genetic polymorphism
Multidrug resistance
Multidrug resistance-associated protein 1 (MRP1/ABCC1)
Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1
期刊论文
Journal of Biological Chemistry, 2007, 卷号: 282, 期号: 12, 页码: 8821-8830
作者:
Yang, Youyun
;
Liu, Yang
;
Dong, Zizheng
;
Xu, Junkang
;
Peng, Hui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
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