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科研机构
上海药物研究所 [14]
合肥物质科学研究院 [2]
数学与系统科学研究院 [1]
内容类型
期刊论文 [17]
发表日期
2021 [17]
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16
作者:
Yuliantie, Elita
;
van der Velden, Wijnand J. C.
;
Labroska, Viktorija
;
Dai, Antao
;
Zhao, Fenghui
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  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
Glucose-dependent insulinotropic polypeptide receptor
G protein-coupled receptor
GPCR structure-function relationship
ERK
cAMP
Arrestin
Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
;
Zhang, Yanan
;
Lv, Pei
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  |  
浏览/下载:43/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Structural insights into the activation of human calcium-sensing receptor
期刊论文
ELIFE, 2021, 卷号: 10, 页码: 24
作者:
Chen, Xiaochen
;
Wang, Lu
;
Cui, Qianqian
;
Ding, Zhanyu
;
Han, Li
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  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
G-protein-coupled receptor
calcium-sensing receptor
cryo-electron microscopy
calcium ions
nanobody
CaSR
GPCR
cryo-EM
None
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 32, 页码: 8
作者:
Wang, Xi
;
Cheng, Xi
;
Zhao, Lihua
;
Wang, Yuzhe
;
Ye, Chenyu
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/11/04
parathyroid hormone receptor 2
cryo-electron microscopy
G protein-coupled receptor
ligand recognition
syndromic short stature
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 15
作者:
Lu, Shaoyong
;
He, Xinheng
;
Yang, Zhao
;
Chai, Zongtao
;
Zhou, Shuhua
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/11/04
Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF
期刊论文
FRONTIERS IN GENETICS, 2021, 卷号: 12, 页码: 14
作者:
Zhou, Guofeng
;
Sun, Shaoyan
;
Yuan, Qiuyue
;
Zhang, Run
;
Jiang, Ping
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/10/26
heart failure with preserved ejection fraction
differentially expressed genes
differentially correlated gene pairs
differential network
molecular docking
Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4
期刊论文
NATURE, 2021, 卷号: 594, 期号: 7864, 页码: 583-+
作者:
Lin, Shuling
;
Han, Shuo
;
Cai, Xiaoqing
;
Tan, Qiuxiang
;
Zhou, Kexiu
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/16
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 6, 页码: 991-1002
作者:
Lu, Yan
;
Liu, Hongyue
;
Yang, Dehua
;
Zhong, Li
;
Xin, Ye
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
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