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浏览/检索结果: 共5条，第1-5条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：70/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors   Emergence of Chinese Drug Discovery Research: Impact of Hit and Lead Identification 期刊论文 JOURNAL OF BIOMOLECULAR SCREENING, 2015, 卷号: 20, 期号: 3, 页码: 318-329 作者:  Zhou, Caihong;  Zhou, Yan;  Wang, Jia;  Zhu, Yue;  Deng, Jiejie 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 review  drug discovery  hit identification  lead generation  compound library   Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals 期刊论文 ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1437-1448 作者:  Hu, Zhe-yi;  Li, Xiu-xue;  Du, Fei-fei;  Yang, Jun-ling;  Niu, Wei 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 pharmacokinetics  distribution  metabolism  excretion  L-P  L-2-Z  carboxylesterase  species difference  prodrug   Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases 期刊论文 JOURNAL OF CHROMATOGRAPHY A, 2011, 卷号: 1218, 期号: 38, 页码: 6646-6653 作者:  Hu, Zheyi;  Sun, Yan;  Du, Feifei;  Niu, Wei;  Xu, Fang 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Simmitecan  Chimmitecan  Irinotecan  Camptothecin  Prodrug  Carboxylesterase  Bis(4-nitrophenyl)phosphate  Pulse gradient chromatography  Matrix effects   Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases 会议论文 作者:  Hu, Zheyi;  Sun, Yan;  Li, Chuan 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08