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上海药物研究所 [25]
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厦门大学 [5]
上海营养与健康研究所 [5]
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大连化学物理研究所 [4]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice
期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10
作者:
Chen, Meng-Ting
;
Huang, Jun-Shang
;
Gao, Ding-Ding
;
Li, Ying-Xia
;
Wang, He-Yao
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
combined treatment
FABP4 inhibitor
liver steatosis
obese type 2 diabetes
rosiglitazone
Activating Adenosine Monophosphate-Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice
期刊论文
HEPATOLOGY, 2021, 卷号: 73, 期号: 6, 页码: 2206-2222
作者:
Lin, Qian
;
Huang, Zhifeng
;
Cai, Genxiang
;
Fan, Xia
;
Yan, Xiaoqing
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Yu, Yan-yan
;
Cui, Shi-chao
;
Zheng, Tian-nan
;
Ma, Hai-jian
;
Xie, Zhi-fu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
insulin resistance
sarsasapogenin
adipose tissue inflammation
macrophage-adipocyte crosstalk
IKK/NF-kappa B
JNK
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 43, 页码: 21732-21738
作者:
Liu, Bin
;
Zhang, Zhijian
;
Hu, Yanyun
;
Lu, Yan
;
Li, Duanzhuo
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
type 2 diabetes
gluconeogenesis
hepatic glucose production
ER stress
USP14
TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56
作者:
Huang, Suling
;
Ma, Shanyao
;
Ning, Mengmeng
;
Yang, Wenji
;
Ye, Yangliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
TGR5
Glucose homeostasis
Insulin resistance
Skeletal muscle
Type 2 diabetes
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Separate and combined associations of physical activity and obesity with lipid-related indices in non-diabetic and diabetic patients
期刊论文
LIPIDS IN HEALTH AND DISEASE, 2019, 卷号: 18, 期号: 无, 页码: 9
作者:
Zhang, Yongliang
;
Yang, Jian
;
Ye, Jun
;
Guo, Qiao
;
Wang, Weimin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/05/21
Physical activity
Obesity
Type 2 diabetes
Dyslipidemia
Triglyceride
High-density lipoprotein cholesterol
Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels
期刊论文
MEDICAL SCIENCE MONITOR, 2019, 卷号: 25, 页码: 3417-3424
作者:
Wang, Hui
;
Fa, Xinxin
;
Qu, Wei
;
Fu, Jindong
;
Fan, Kaiyun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/11
Diabetes Mellitus
Gastrectomy
Ghrelin
Glucagon-Like Peptide 1
Transposition of Great Vessels
Effects of a diet with or without physical activity on angiopoietin-like protein 8 concentrations in overweight/obese patients with newly diagnosed type 2 diabetes: a randomized controlled trial
期刊论文
ENDOCRINE JOURNAL, 2019, 卷号: 66, 期号: 1, 页码: 89-105
作者:
Hu, Hao[1]
;
Yuan, Guoyue[2]
;
Wang, Xinchen[3]
;
Sun, Jin[4]
;
Gao, Zhaohua[5]
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/24
ANGPTL8
Betatrophin
Lifestyle intervention
Obesity
Type 2 diabetes
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