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Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:
Xiang, Hao-Yue
;
Chen, Yan-Hong
;
Wang, Yi
;
Zhang, Xi
;
Ding, Jian
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Antiproliferative
Cancer
Therapy
PI3K inhibitors
Pyrrolo [2,1-f][1,2,4] triazine
Kinase
Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors
期刊论文
Journal of Controlled Release, 2019, 卷号: 309
作者:
Zhang, Xueqiong
;
Shen, Limei
;
Liu, Qi
;
Hou, Lin
;
Huang, Leaf
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Spautin-A41 Attenuates Cerulein-Induced Acute Pancreatitis through Inhibition of Dysregulated Autophagy
期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 42, 期号: 11, 页码: 1789-1798
作者:
Dong, Kai
;
Chen, Xia
;
Xie, Liping
;
Yu, Lanting
;
Shen, Mengjun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/11
spautin-A41
pancreatitis
autophagy
spautin-1
Class III
phosphatidylinositol 3 (PI3) kinase
CKLF1 aggravates neointimal hyperplasia by inhibiting apoptosis of vascular smooth muscle cells through PI3K/AKT/NF-kappa B signaling
期刊论文
2019, 卷号: 117, 页码: 108986
作者:
Duan, Yanyu
;
Zhang, Yongbao
;
Qu, Chengjia
;
Yu, Weidong
;
Tana
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/01/03
Chemokine-like factor 1
Vascular smooth muscle cells
Apoptosis
Neointimal hyperplasia
PI3 kinase
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
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  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:
Liang, Xiaofei
;
Li, Feng
;
Chen, Cheng
;
Jiang, Zongru
;
Wang, Aoli
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/10
PI3K delta
Kinase inhibitor
Acute myeloid leukemia
Structure-activity relationship
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2017, 卷号: 87, 期号: 3, 页码: 145-152
作者:
Tang, D (Tang, Dan)
;
Chen, QB (Chen, Qi-Bin)
;
Xin, XL (Xin, Xue-Lei)
;
Aisa, HA (Aisa, Haji-Akber)
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2017/04/05
Diabetes
Norditerpenoid alkaloids
Anti-diabetic activity
Glucose metabolism
Protein tyrosine phosphatase 1B
PI3K/Akt signaling pathway
Discovery of new BTK inhibitors with B cell suppression activity bearing a 4,6-substituted thieno[3,2-d] pyrimidine scaffold
期刊论文
RSC ADVANCES, 2017, 卷号: 7, 期号: 42, 页码: 26060-26069
作者:
Zhang, Qiumeng
;
Zhang, Luyao
;
Yu, Jie
;
Li, Heng
;
He, Shijun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Graphene Enhances Cellular Proliferation through Activating the Epidermal Growth Factor Receptor
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, 卷号: 64, 期号: 29, 页码: 5909-5918
作者:
Liu, Wei
;
Sun, Cheng
;
Liao, Chunyang
;
Cui, Lin
;
Li, Haishan
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  |  
浏览/下载:54/0
  |  
提交时间:2017/03/27
graphene
cell proliferation
EGFR
cytotoxicity
biosafety
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