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大连化学物理研究所 [7]
上海药物研究所 [5]
山东大学 [5]
大连理工大学 [2]
湖南大学 [2]
合肥物质科学研究院 [2]
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期刊论文 [26]
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2021 [1]
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物理化学 [1]
生命有机化学 [1]
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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219
作者:
Lu, Tian
;
Li, Yong
;
Lu, Wenchao
;
Spitters, Twgm
;
Fang, Xueyu
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/12/01
Hippo pathway
TEAD3
Covalent inhibitor
Palmitoylation inhibitor
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu
期刊论文
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10
作者:
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
;
Zhang, Feng
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2019/05/08
Bufotalin
Cytochrome p450 3a (cyp3a)
Hydroxylation
Human liver microsomes (hlms)
Docking simulations
Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 136
作者:
Qi, Xiaoyi
;
Dou, Tongyi
;
Wang, Zhongqiong
;
Wu, Jianming
;
Yang, Ling
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
CYP2A6
Inhibitor
7-Hydroxycoumarin
Structure-activity relationship
Isoform
Selectivity
Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 136, 页码: 104944
作者:
Qi, Xiaoyi
;
Dou, Tongyi
;
Wang, Zhongqiong
;
Wu, Jianming
;
Yang, Ling
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/02
CYP2A6
Inhibitor
7-Hydroxycoumarin
Structure-activity relationship
Isoform
Selectivity
Glucuronidation of d-Luciferin In Vitro: Isoform Selectivity and Kinetics Characterization
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2019, 卷号: 44, 页码: 549-556
作者:
Xia, Yangliu
;
Pang, Huilin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/02
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.
期刊论文
Bioorganic & medicinal chemistry letters, 2019
作者:
Kai Cheng
;
Shiyu Li
;
Xiao Lv
;
Yongbin Tian
;
Haiyan Kong
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/12/13
Fragment-based drug design
Isatin
Isoform selectivity
Structure activity relationship
hMAO-B
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure
期刊论文
Bioorganic & Medicinal Chemistry Letters, 2019
作者:
Kai Cheng
;
Shiyu Li
;
Xiao Lv
;
Yongbin Tian
;
Haiyan Kong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/17
hMAO-B
isatin
isoform
selectivity
fragment-based
drug
design
structure
activity
relationship
Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 26, 页码: E5896-E5905
作者:
Dai, Jianye
;
Liang, Kai
;
Zhao, Shan
;
Jia, Wentong
;
Liu, Yuan
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/04/09
Baicalin
Cpt1
Obesity
Chemical Proteomics
Steatosis
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors
期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 151, 页码: 9-17
作者:
Ma C.-C.
;
Zhang C.-M.
;
Tang L.-Q.
;
Liu Z.-P.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
B-Cell inhibition
PI3K isoform selectivity
PI3Kδ inhibitor
PI3Kδ/γ inhibitors
Quinazolinones
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