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科研机构
河南大学 [5]
上海药物研究所 [3]
山东大学 [2]
内容类型
期刊论文 [10]
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2021 [1]
2020 [1]
2017 [1]
2016 [2]
2015 [3]
2014 [1]
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Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199
作者:
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Liang, Xiaoying
;
Lan, Yuan
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12
作者:
Han, Fanghui
;
Ning, Mengmeng
;
Cao, Hua
;
Ye, Yangliang
;
Feng, Ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Soft drug
TGR5
GLP-1
Gallbladder-filling effects
Rapid metabolism
Carboxylic ester
The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-kappa B and STAT3 signaling pathways
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 33, 页码: 54378-54387
作者:
Su Jia[1]
;
Zhang Qiqi[2]
;
Qi Hui[3]
;
Wu Linlin[4]
;
Li Yuanqiang[5]
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/23
Gpbar1
TGR5
renal inflammation
STAT3
NF-kappa B
Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339
作者:
Chen, Zhixiang
;
Ning, Mengmeng
;
Zou, Qingan
;
Cao, Hua
;
Ye, Yangliang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Takeda G-protein-coupled receptor 5 agonist
bioisostere
microsomal clearance
structure-activity relationship
TGR5, Not Only a Metabolic Regulator
期刊论文
FRONTIERS IN PHYSIOLOGY, 2016, 卷号: 7
作者:
Guo, Cong[1]
;
Chen, Wei-Dong[2]
;
Wang, Yan-Dong[3]
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
TGR5
Gpbar1
GPCR
bile acids
receptor
Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-on-chronic hepatitis B liver failure
期刊论文
Journal of viral hepatitis., 2015, 卷号: 22, 期号: 2, 页码: 112-119
作者:
Gao, S.
;
Ji, X-F
;
Li, F.
;
Sun, F-K
;
Zhao, J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
acute-on-chronic hepatitis B liver failure
DNA methylation
G-protein-coupled bile acid receptor Gpbar1
methylation-specific polymerase chain reaction
prognosis
The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-kappa B Signaling Pathway
期刊论文
FRONTIERS IN PHARMACOLOGY, 2015, 卷号: 6, 页码: 287
作者:
Guo, Cong[1]
;
Qi, Hui[2]
;
Yu, Yingjie[3]
;
Zhang, Qiqi[4]
;
Su, Jia[5]
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/23
tgr5
GPBAR1
GPCR
NF-kappa B
gastric inflammation
The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 33, 页码: 34402-34413
作者:
Guo, Cong[1]
;
Su, Jia[2]
;
Li, Zhijun[3]
;
Xiao, Rui[4]
;
Wen, Jianxun[5]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
Gpbar1
TGR5
gastric cancer
STAT3
bile acid receptor
Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma
期刊论文
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2014, 卷号: 11, 期号: 2, 页码: 164-171
作者:
Han, Li-Yan
;
Fan, Yu-Chen
;
Mu, Nan-Nan
;
Gao, Shuai
;
Li, Feng
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
TGR5
DNA methylation
Hepatocellular carcinoma
MSP
serum
Deficiency of G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Enhances Chemically Induced Liver Carcinogenesis (Retracted article. See vol. 58, pg. 1194, 2013)
期刊论文
HEPATOLOGY, 2013, 卷号: 57, 期号: 2, 页码: 656-666
作者:
Chen, Wei-Dong[1]
;
Yu, Donna[2]
;
Forman, Barry M.[3]
;
Huang, Wendong[4]
;
Wang, Yan-Dong[5]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/23
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