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上海药物研究所 [6]
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期刊论文 [19]
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Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS
期刊论文
FOOD & FUNCTION, 2023, 卷号: 14, 期号: 17, 页码: 7869
作者:
Jiang, Sirong
;
Wang, Luya
;
Jia, Wenjing
;
Wu, Di
;
Wu, Li
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/01
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
Gandou decoction, a Chinese medicinal formula, in the treatment of hepatic injury by Wnt/beta-catenin pathway regulation in models of Wilson disease
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2020, 卷号: 9
作者:
Gao, Manli
;
Geng, Hao
;
Wu, Peng
;
Dong, Jianjian
;
Li, Hai
收藏
  |  
浏览/下载:121/0
  |  
提交时间:2020/11/30
Wilson disease (WD)
liver injury
Gandou decoction (GDD)
Wnt/beta-catenin pathway
oxidative stress
Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2019, 卷号: 71, 期号: 1, 页码: 291-305
作者:
Wu, Beibei
;
Wang, Yujing
;
Shi, Chenggang
;
Chen, Yao
;
Yu, Lexiang
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/10/25
Advanced glycation end products
brain-derived neurotrophic factor
GSK-3 beta oxidative stress
ribosylation
tau hyperphosphorylation
The protective effect of kaempferol on heart via the regulation of Nrf2, NF-kappa beta, and PI3K/Akt/GSK-3 beta signaling pathways in isoproterenol-induced heart failure in diabetic rats
期刊论文
DRUG DEVELOPMENT RESEARCH, 2019, 卷号: 80, 期号: 3, 页码: 294-309
作者:
Zhang, Long
;
Guo, Zhaoxia
;
Wang, Yan
;
Geng, Jun
;
Han, Shuyi
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
apoptosis
diabetes
heart failure
inflammation
oxidative stress
Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 622-633
作者:
Sun, Guanglong
;
Wang, Junwei
;
Guo, Xiaodan
;
Lei, Min
;
Zhang, Yinan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
LX2343 derivatives
Neuroprotective agents
Alzheimer's disease
Structural modifications
Structure-activity relationships
Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3 beta
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Fan, Xiaoye
;
Lv, Hongming
;
Wang, Lidong
;
Deng, Xuming
;
Ci, Xinxin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
acetaminophen APAP
hepatotoxicity
Isoorientin Iso
Nrf2
oxidative stress
LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Wang, Yi-yang
;
Xu, Xin
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
LX2343
cognitive deficits
oxidative stress
tauopathy
mitochondria
GSK-3 beta inhibitor
neuroprotection
ICV-STZ rats
Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway
期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 4
作者:
Wang, Jing
;
Liu, Huaide
;
Zhang, Xuan
;
Li, Xinpeng
;
Geng, Lihua
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2017/10/09
Sulfated Hetero-polysaccharides
Pi3k/akt
Phosphorylate
Sh-sy5y
Oxidative Stress
Hypoglycemic effect of the polyphenols rich extract from Rose rugosa Thunb on high fat diet and STZ induced diabetic rats
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2017, 卷号: 200, 期号: 3, 页码: 174-181
作者:
Liu, L (Liu, Liu)
;
Tang, D (Tang, Dan)
;
Zhao, HQ (Zhao, Haiqing)
;
Xin, XL (Xin, Xuelei)
;
Aisa, HA (Aisa, Haji Akber)
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2017/05/19
Rose rugosa Thunb
Diabetes
Antioxidant
PI3K/AKT signaling pathway
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