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大连化学物理研究所 [7]
上海药物研究所 [4]
上海有机化学研究所 [3]
四川大学 [3]
清华大学 [2]
北京大学 [2]
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期刊论文 [37]
会议论文 [3]
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Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13
作者:
Tang, Xuehang
;
Ning, Mengmeng
;
Ye, Yangliang
;
Gu, Yipei
;
Yan, Hongyi
收藏
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浏览/下载:49/0
  |  
提交时间:2021/11/04
FXR agonist
Ketoxime ether
Target genes
Liver
blood ratio
Systemic activation
Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
期刊论文
MEDICINE, 2019, 卷号: 98, 期号: 31, 页码: 11
作者:
Ma, Zhenhua
;
Wang, Xiaomei
;
Yin, Peiyuan
;
Wu, Ruihong
;
Zhou, Lina
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  |  
浏览/下载:78/0
  |  
提交时间:2019/12/02
bile acid
biomarkers
drug induced liver injury
serum metabolic profiling
UHPLC-MS/MS
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
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  |  
浏览/下载:72/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Delta 4-3-oxosteroid-5 beta-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes
期刊论文
WORLD JOURNAL OF GASTROENTEROLOGY, 2019, 卷号: 25, 期号: 7
作者:
Zhang, Mei-Hong
;
Setchell, Kenneth D. R.
;
Zhao, Jing
;
Gong, Jing-Yu
;
Lu, Yi
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  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Delta 4-3-oxosteroid-5 beta-reductase deficiency
Mass spectrometry
Bile acid synthesis disorder
Chenodeoxycholic acid
Ursodeoxycholic acid
Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1
期刊论文
Biological Chemistry, 2019, 卷号: Vol.400 No.5, 页码: 625-628
作者:
Fan L.
;
Joseph J.F.
;
Durairaj P.
;
Parr M.K.
;
Bureik M.
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  |  
浏览/下载:13/0
  |  
提交时间:2019/11/21
bile acid
cytochrome P450
fission yeast
liver
S. pombe
steroid hydroxylation
Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2018, 卷号: 32, 期号: 2
作者:
Zhu, Haiyan
;
Chen, Mingcang
;
Shi, Xunlong
;
Shi, Chenchen
;
Huang, Chenggang
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  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
antiviral research
component analysis
Influenza A virus
LC/QTOF/MS
Tanreqing Injection
Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature
期刊论文
WORLD JOURNAL OF GASTROENTEROLOGY, 2018, 卷号: 24, 期号: 35
作者:
Wang, Hui-Hui
;
Wen, Fei-Qiu
;
Dai, Dong-Ling
;
Wang, Jian-She
;
Zhao, Jing
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Aldo-keto reductase family 1 member D1
Cholestasis
Congenital bile acid synthesis defect
Gene mutation
Hydrophilic Interaction Liquid Chromatography Coupled with Mass Spectrometry for Serum Metabolomics Analysis of Bladder Cancer
期刊论文
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2017, 卷号: 45, 期号: 12, 页码: 1921-1929
作者:
Zheng Si-Jia
;
Wang Qing-Qing
;
Wang Xiao-Lin
;
Zhao Xin-Jie
;
Xu Guo-Wang
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/06/20
Zwitterionic Hydrophilic Interaction Liquid Chromatography/mass Spectrometry
Metabolomics
Bladder Cancer
Polar Metabolites
The influence of diet on the grass carp intestinal microbiota and bile acids
期刊论文
AQUACULTURE RESEARCH, 2017, 卷号: 48, 期号: 9, 页码: 4934-4944
作者:
Zhang, Jing
;
Xiong, Fan
;
Wang, Gui-Tang
;
Li, Wen-Xiang
;
Li, Ming
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  |  
浏览/下载:21/0
  |  
提交时间:2019/08/01
grass carp
gut microbe
bile acids
diet
Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Zhang, Jing
;
Li, Huating
;
Zhou, Hu
;
Fang, Li
;
Xu, Jingjing
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
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