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Combined everolimus and endocrine therapy in advanced HR-positive, HER2-negative Chinese breast cancer patients: a retrospective study
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9
作者:
Shen, Xia-Bo
;
Li, Guang-Liang
;
Zheng, Ya-Bing
;
Chen, Zhan-Hong
;
Cao, Wen-Ming
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/11/01
Advanced breast cancer (ABC)
aromatase inhibitors (AIs)
everolimus (EVE)
fulvestrant (FUL)
retrospective study
Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:
Xiang, Hao-Yue
;
Wang, Xiang
;
Chen, Yan-Hong
;
Zhang, Xi
;
Tan, Cun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
PI3K
Pyrrolo[2,1-f][1,2,4]triazine
Anti-cancer
Target therapy
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:
Zhang, Jinhua
;
Si, Jing
;
Gan, Lu
;
Zhou, Rong
;
Guo, Menghuan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/12
DNA damage
DNA repair
particle therapy
photon therapy
radiosensitizer
Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 3, 页码: 2977-2984
作者:
Wang, Hui-Li
;
Liu, Yan-Chun
;
Long, Ming-Peng
;
Zheng, Chuan
;
Yang, Jia-Hui
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2019/11/07
receptor tyrosine kinase-like orphan receptor 1
lung adenocarcinoma
erlotinib resistance
AKT
mammalian target of rapamycin
small interfering RNA
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2209-2226
作者:
Li, Heng
;
Fan, Chen
;
Feng, Chunlan
;
Wu, Yanwei
;
Lu, Huimin
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: Vol.40 No.2, 页码: 268-278
作者:
Gao, Ming-zhao
;
Wang, Hong-bin
;
Chen, Xiang-ling
;
Cao, Wen-ting
;
Fu, Li
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/13
BRAF-mutant melanoma
MAPK pathway inhibitors
acquired resistance
P70S6K
RSK
rpS6
G(1)/G(0) phase arrest
mTOR inhibitor
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