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科研机构
上海药物研究所 [507]
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期刊论文 [390]
项目 [110]
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Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 79-90
作者:
Li, Jin-Feng
;
Zeng, Yan-Bo
;
Li, Wang-Sheng
;
Luo, Hui
;
Zhang, Hai-Yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
Sarcophyton glaucum
Cembranoids
Configuration determination
X-ray diffraction
NMR spectroscopy
Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection
期刊论文
CARBOHYDRATE POLYMERS, 2022, 卷号: 275, 页码: 8
作者:
Zhang, Shihai
;
Pei, Rongjuan
;
Li, Meixia
;
Su, Haixia
;
Sun, Hao
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/12/16
COVID-19
SARS-CoV-2
Angiotensin converting enzyme 2 (ACE2)
3CL protease
Ecklonia kurome Okam
Polysaccharide
Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5
作者:
Wang, Leiming
;
Li, Xin
;
Cui, Hong
;
Lei, Xinsheng
;
Liu, Hongchun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/12/01
Marine nature products
Plocabulin
PM060184
Synthesis
Antiproliferation
New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp.
期刊论文
TETRAHEDRON, 2021, 卷号: 96, 页码: 7
作者:
Chen, Bao
;
Li, Wang-Sheng
;
Gu, Yu-Cheng
;
Zhang, Hai-Yan
;
Luo, Hui
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/11/04
Sponge
Halichondria sp
Anti-inflammatory activity
Sesquiterpenes
Center for high Performance Computing and System Simulation, Pilot National Laboratory for Marine Science and Technology (Qingdao)
项目
资助机构: Center for high Performance Computing and System Simulation, Pilot National Laboratory for Marine Science and Technology (Qingdao), 2021-
-
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2021/11/04
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 15
作者:
Lu, Shaoyong
;
He, Xinheng
;
Yang, Zhao
;
Chai, Zongtao
;
Zhou, Shuhua
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/11/04
Polyoxygenated cembranoids from the Hainan soft coral Lobophytum crassum
期刊论文
TETRAHEDRON, 2021, 卷号: 90, 页码: 7
作者:
Yin, Fang-Zhou
;
Yao, Li-Gong
;
Zhang, Zai-Yong
;
Wang, Jian-Rong
;
Wang, Hong
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
Soft coral
Marine natural products
Cembranoids
Stereochemistry
Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 111, 页码: 8
作者:
Zhang, Cong
;
Li, Heng
;
Liu, Jin
;
Liu, Moting
;
Zhang, Hao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
Marine natural product
Cembranoid
Anti-inflammation
molecular docking
structuremodification
Structure Activity Relationship
Ximaoglaucumins A-F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 38, 页码: 10
作者:
Shen, Shou-Mao
;
Li, Wang-Sheng
;
Ding, Xun
;
Luo, Hui
;
Zhang, Hai-Yan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/08/17
Soft coral
Sarcophyton glaucum
Cembranoids
Anti-inflammation
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
收藏
  |  
浏览/下载:144/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
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