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科研机构
上海药物研究所 [10]
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期刊论文 [10]
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2021 [1]
2020 [1]
2019 [1]
2018 [2]
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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
A rapid and convenient derivatization method for quantitation of short-chain fatty acids in human feces by ultra-performance liquid chromatography/tandem mass spectrometry
期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2020, 卷号: 34, 期号: 9, 页码: 11
作者:
Fu, Huan
;
Zhang, Qing-li
;
Huang, Xiao-wu
;
Ma, Zheng-hua
;
Zheng, Xiao-li
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  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Acylhydrazone Derivatives Containing Carbazole Moity
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 2, 页码: 491-499
作者:
Li Yingjun
;
Wang Siyuan
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
acylhydrazone
carbazole
synthesis
Cdc25B and PTP1B inhibitor
molecular docking
Synthesis and Cell Division Cycle 25B Phosphatase/Protein Tyrosine Phosphatase 1B Inhibitory Activity Evaluation of Novel Acylthiourea Derivatives
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 5, 页码: 1242-1250
作者:
Li Yingjun
;
Wang Siyuan
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
acylthiourea
carbazole
synthesis
Cdc25B and PTP1B inhibitors
molecular docking
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:
Xu, Yi-xiang
;
Wang, Huan
;
Li, Xiao-kang
;
Dong, Sheng-nan
;
Liu, Wen-wen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
MAO-B inhibitors
Metal chelating agents
Alzheimer's disease
The metabolic ER stress sensor IRE1 alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity
期刊论文
NATURE IMMUNOLOGY, 2017, 卷号: 18, 期号: 5, 页码: 519-529
作者:
Shan, Bo
;
Wang, Xiaoxia
;
Wu, Ying
;
Xu, Chi
;
Xia, Zhixiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Synthesis and Cell Division Cycle 25B Phosphatase and Protein Tyrosine Phosphatase 1B Inhibitory Activity Evaluation of Novel 3,6-Disubstituted Triazolothiadiazole Derivatives
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 37, 期号: 2, 页码: 485-495
作者:
Li Yingjun
;
Li Jiyang
;
Peng Lina
;
Gao Lixin
;
Jin Kun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
triazolothiadiazole
benzimidazole
arylsulfonyl
synthesis
Cdc25B and PTP1B inhibitors
Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Wang, Jiwen
;
Yao, Yanli
;
Ming, Yue
;
Shen, Sheng
;
Wu, Nan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 112, 页码: 81-90
作者:
Gong, Chao-Jun
;
Gao, An-Hui
;
Zhang, Yang-Ming
;
Su, Ming-Bo
;
Chen, Fei
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Bisthiazole
Histone deacetylases
ZBG
Trifluoromethyl ketones
Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 5, 页码: 3149-3160
作者:
Deng, Si-Si
;
Wu, Le-Yu
;
Wang, Ya-Chao
;
Cao, Peng-Rong
;
Xu, Lei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Microtubule
Microtubule-associated Protein (MAP)
Neurite Outgrowth
Protein Kinase A (PKA)
Tau Protein (Tau)
MARK2
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