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科研机构
上海药物研究所 [144]
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期刊论文 [140]
会议论文 [4]
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2021 [16]
2020 [23]
2019 [11]
2018 [18]
2017 [10]
2016 [9]
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Pharmacolo... [6]
Chemistry [1]
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Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1
期刊论文
Journal of Hematology & Oncology, 2021, 卷号: 14, 期号: 1
作者:
Shi,Zhaopeng
;
Gan,Guifang
;
Xu,Xiang
;
Zhang,Jieying
;
Yuan,Yuan
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
3-Hydroxyanthronic acid (3-HAA)
Kynurenine
YY1
DUSP6
Hepatocellular carcinoma (HCC)
Tryptophan metabolism
Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer
期刊论文
ADVANCED MATERIALS, 2021, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Tang, Yang
;
Zou, Zhifeng
;
Jiao, Shi
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
antigen presentation
autophagy inhibition
immune resistance
immunotherapy
prodrug nanovesicles
Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Huang, He-ming
;
Fan, Shi-jie
;
Zhou, Xiao-ru
;
Liu, Yan-jun
;
Li, Xiao
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
nonalcoholic steatohepatitis
inflammation
histone deacetylase inhibitor
givinostat
epigenetics
Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus
期刊论文
PLOS PATHOGENS, 2021, 卷号: 17, 期号: 7, 页码: 21
作者:
Shi, Hengzhi
;
Huang, Xiaocui
;
Chen, Xueqiu
;
Yang, Yi
;
Wang, Zhao
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/11/04
Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines
期刊论文
TETRAHEDRON LETTERS, 2021, 卷号: 72, 页码: 4
作者:
Shi, Yunkai
;
Chen, Chao
;
Yang, Yaxi
;
Zhou, Bing
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/08/17
C-H activation
1,7-Fused indoline
Enynes
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
期刊论文
MOLECULAR MEDICINE REPORTS, 2021, 卷号: 23, 期号: 5, 页码: 12
作者:
Huang, He-Ming
;
Zhou, Xiao-Ru
;
Liu, Yan-Jun
;
Fan, Shi-Jie
;
Liao, Li-Ping
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
liver fibrosis
hepatic stellate cell
histone deacetylase inhibitor
epigenetics
givinostat
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