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科研机构
上海药物研究所 [214]
内容类型
期刊论文 [207]
会议论文 [6]
专著章节 [1]
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2021 [20]
2020 [17]
2019 [25]
2018 [15]
2017 [26]
2016 [16]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
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  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12, 页码: 15
作者:
Fu, Yadong
;
Xiao, Zhun
;
Tian, Xiaoting
;
Liu, Wei
;
Xu, Zhou
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/01/04
traditional Chinese medicine
JY5 formula
fuzheng huayu
hepatic fibrosis
notch signaling pathway
Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2021, 页码: 14
作者:
Duan, Nianxiu
;
Li, Junjun
;
Song, Sha
;
Wang, Feng
;
Yang, Yiwei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/11/04
drug delivery
pancreatic cancer
prodrugs
smart liposomes
tumor-specific vascular promotion
Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 4, 页码: 22
作者:
Gao, Mengqing
;
Wang, Jin
;
Rousseaux, Sophie
;
Tan, Minjia
;
Pan, Lulu
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy
期刊论文
CHEMICAL SCIENCE, 2021, 页码: 9
作者:
Dou, Wei-Tao
;
Xu, Fugui
;
Xu, Chen-Xi
;
Gao, Jie
;
Ru, Hong-Bo
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  |  
浏览/下载:81/0
  |  
提交时间:2021/08/17
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
Lan, Xiao-fang
;
Olaleye, Olajide E.
;
Lu, Jun-lan
;
Yang, Wei
;
Du, Fei-fei
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T-reg cells
期刊论文
NATURE NEUROSCIENCE, 2021, 页码: 33
作者:
Xu, Zhipeng
;
Zhang, Xiaoyun
;
Chang, Hao
;
Kong, Yue
;
Ni, Yangyue
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/05/24
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