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科研机构
上海药物研究所 [108]
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期刊论文 [106]
会议论文 [2]
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2021 [15]
2020 [13]
2019 [11]
2018 [8]
2017 [8]
2016 [10]
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共108条,第1-10条
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A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
CsCCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 39, 页码: 11626-11636
作者:
Liang, Nan
;
Yao, Ming-Dong
;
Wang, Ying
;
Liu, Jia
;
Feng, Lu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/12/01
crocetin
CCD2
access tunnel engineering
Saccharomyces cerevisiae
Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis
期刊论文
ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 页码: 14
作者:
Liu, Siyu
;
Mao, Hui
;
Qiao, Jin
;
Zhang, Xiaoning
;
Lu, Yangbin
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2021/11/04
Iridium
C-H activation
[3+2] annulation
Tetrasubstituted alkene
pyrrolo[1,2-a]indole
Structural insights into the activation of human calcium-sensing receptor
期刊论文
ELIFE, 2021, 卷号: 10, 页码: 24
作者:
Chen, Xiaochen
;
Wang, Lu
;
Cui, Qianqian
;
Ding, Zhanyu
;
Han, Li
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
G-protein-coupled receptor
calcium-sensing receptor
cryo-electron microscopy
calcium ions
nanobody
CaSR
GPCR
cryo-EM
None
Redox-Neutral Rhodium(III)-Catalyzed Chemospecific and Regiospecific [4+1] Annulation between Indoles and Alkenes for the Synthesis of Functionalized Imidazo[1,5-a]indoles
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 15, 页码: 10591-10607
作者:
Zhao, Fei
;
Qiao, Jin
;
Lu, Yangbin
;
Zhang, Xiaoning
;
Dai, Long
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/11/04
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12
作者:
Su, Haixia
;
Yao, Sheng
;
Zhao, Wenfeng
;
Zhang, Yumin
;
Liu, Jia
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/08/17
Activating Adenosine Monophosphate-Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice
期刊论文
HEPATOLOGY, 2021, 卷号: 73, 期号: 6, 页码: 2206-2222
作者:
Lin, Qian
;
Huang, Zhifeng
;
Cai, Genxiang
;
Fan, Xia
;
Yan, Xiaoqing
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
期刊论文
PHARMACEUTICALS, 2021, 卷号: 14, 期号: 5, 页码: 22
作者:
Anicic, Neda
;
Gasic, Uros
;
Lu, Feng
;
Ciric, Ana
;
Ivanov, Marija
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Nepeta
nepetalactone
1,5,9-epideoxyloganic acid
antimicrobial activity
antibiofilm
immunomodulatory effects
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
Lan, Xiao-fang
;
Olaleye, Olajide E.
;
Lu, Jun-lan
;
Yang, Wei
;
Du, Fei-fei
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
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