QQ客服 官方微博 反馈留言

浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11 作者:  Fan, Shijie;  Yue, Liyan;  Wan, Wei;  Zhang, Yuanyuan;  Zhang, Bidong 收藏  |  浏览/下载：80/0  |  提交时间：2021/12/16 covalent modification  probes  proteome  LC3  post-translational modification   Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090 作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan 收藏  |  浏览/下载：23/0  |  提交时间：2022/01/04 Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy 期刊论文 Chinese Medicine, 2021, 卷号: 16, 期号: 1 作者:  Wu,Gaosong;  Zhao,Jing;  Zhao,Jing;  Song,Nixue;  Zheng,Ningning 收藏  |  浏览/下载：24/0  |  提交时间：2021/12/01 Coronary heart disease  Syndrome differentiation  Traditional Chinese Medicine  Proteomics  Metabolomics  Network pharmacology   Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11 作者:  Li, Bo;  Li, Heng;  Zhu, Zhengdan;  Xiang, Caigui;  Xu, Zhijian 收藏  |  浏览/下载：99/0  |  提交时间：2021/11/04 Anti-inflammatory activity  TNF alpha  ER beta  IBD Arylisoquinolones   Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020) 期刊论文 MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1 作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：58/0  |  提交时间：2021/11/04 Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文 Molecular Cancer, 2021, 卷号: 20, 期号: 1 作者:  Zhang,Tao;  Qu,Rong;  Chan,Shingpan;  Lai,Mengzhen;  Tong,Linjiang 收藏  |  浏览/下载：41/0  |  提交时间：2021/11/04 Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12 作者:  Lin, Tingting;  Li, Jiacheng;  Liu, Liping;  Li, Yuanqing;  Jiang, Hualiang 收藏  |  浏览/下载：72/0  |  提交时间：2021/05/24 CDK2 inhibitor  Selectivity  Anti-proliferative potency   Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文 CHEMMEDCHEM, 2021, 页码: 12 作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao 收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24 CHK1 inhibitor  diaminopyrimidine  DNA damage response  oral bioavailability   S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis 期刊论文 CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 卷号: 11, 期号: 3, 页码: 697-724 作者:  Zhang, Linqiang;  Zhang, Zhiguo;  Li, Chengbin;  Zhu, Tingting;  Gao, Jing 收藏  |  浏览/下载：49/0  |  提交时间：2021/05/24 NAFLD  S100A11  FOXO1  Autophagy  Lipid Metabolism   A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文 DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959 作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua 收藏  |  浏览/下载：35/0  |  提交时间：2021/08/17 TPN171H  PDE5 inhibitor  safety  pharmacokinetics  food effect  healthy subjects