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浏览/检索结果: 共33条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：101/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：130/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Chen, Zhuo;  Tong, Lin-Jiang;  Tang, Bai-You;  Liu, Hong-Yan;  Wang, Xin 收藏  |  浏览/下载：103/0  |  提交时间：2019/01/08 Discovery of JND3229 as a New EGFR(C797S) Mutant Inhibitor with In Vivo Monodrug Efficacy 期刊论文 ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 11, 页码: 1123-1127 作者:  Lu, Xiaoyun;  Zhang, Tao;  Zhu, Su-Jie;  Xun, Qiuju;  Tong, Lingjiang 收藏  |  浏览/下载：108/0  |  提交时间：2019/01/08 EGFR(C797s)  Clinical resistance  Fourth-generation nhibitors  Monodrug efficacy   Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1768-1776 作者:  Liu, Ying-Qiang;  Wang, Ya-Nan;  Lu, Xiao-Yun;  Tong, Lin-Jiang;  Li, Yan 收藏  |  浏览/下载：111/0  |  提交时间：2019/01/08 CSF-1R  small-molecule inhibitor  macrophage  myeloid leukemia   Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Meng, Jian;  Liu, Xiao-Yun;  Ma, Sheng;  Zhang, Hua;  Yu, Song-da 收藏  |  浏览/下载：99/0  |  提交时间：2019/01/08 Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors 期刊论文 Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288 作者:  Cheng, Zhi-Qiang;  Zhu, Kong-Kai;  Zhang, Juan;  Song, Jia-Li;  Muehlmann, Luis Alexandre 收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08 Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9, 页码: 1544-1552 作者:  Lu, Tian;  Hu, Jun-chi;  Lu, Wen-chao;  Han, Jie;  Ding, Hong 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 AlphaScreen  high-throughput screening  SMARCA2  bromodomain  small molecule inhibitor   HLA-A*02:07 Allele Associates with Clarithromycin-Induced Cutaneous Adverse Drug Reactions in Chinese Patients 期刊论文 BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 123, 期号: 3, 页码: 308-313 作者:  Chen, Sheng-An;  Zhang, Li-Rong;  Yang, Fan-Ping;  Yang, Lin-Lin;  Yang, Ying 收藏  |  浏览/下载：49/0  |  提交时间：2019/01/08