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中国医学科学院 北... [25]
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期刊论文 [25]
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2019 [4]
2018 [4]
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专题:中国医学科学院 北京协和医学院
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hERG optimizations of IMB1603, discovery of alternative benzothiazinones as new antitubercular agents
期刊论文
2019, 卷号: 179, 页码: 208-217
作者:
Lv Kai
;
Wang Apeng
;
Tao Zeyu
;
Fu Lei
;
Liu Hongtao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/03
Antitubercular agents
Benzothiazinones
Structure-activity relationships
hERG
Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship
期刊论文
2019, 卷号: 61, 页码: 104642
作者:
Fan Xiaoqing
;
Bai Jie
;
Zhao Shengyu
;
Hu Minwan
;
Sun Yanhong
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/03
BCRP
Flavonoids
Inhibition
Molecular mechanism
Structure-activity relationships
Synthesis and antitubercular evaluation of reduced lipophilic imidazo [1,2-a]pyridine-3-carboxamide derivatives
期刊论文
2019, 卷号: 165, 页码: 11-17
作者:
Wang, Hongjian
;
Wang, Apeng
;
Gu, Jian
;
Fu, Lei
;
Lv, Kai
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/01/03
Antitubercular agents
imidazo[1
2-a]pyridine carboxamides
structure-activity relationships
Pharmacokinetics
Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships
期刊论文
2019, 卷号: 369, 页码: 49-59
作者:
Bai, Jie
;
Zhao, Shengyu
;
Fan, Xiaoqing
;
Chen, Yonghui
;
Zou, Xiaowen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/01/03
Flavonoids
P-glycoprotein
Inhibition
Structure-activity relationships
Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents
期刊论文
2018, 卷号: 9, 期号: 7, 页码: 741-745
作者:
Li, Linhu
;
Lv, Kai
;
Yang, Yupeng
;
Sun, Jingquan
;
Tao, Zeyu
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
Antitubercular agents
N-benzyl 3
5-dinitrobenzamides
structure-activity relationships
pharmacokinetics
Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives
期刊论文
2018, 卷号: 157, 页码: 994-1004
作者:
Tao, Zeyu
;
Cao, Ruiyuan
;
Yan, Yunzheng
;
Huang, Guocheng
;
Lv, Kai
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/03
Anti-Zika virus
Sinefungin
EPZ004777
Structure-activity relationships
Methyltransferases
Syntheses and structure-activity relationships on antibacterial and anti-ulcerative colitis properties of quaternary 13-substituted palmatines and 8-oxo-13-substituted dihydropalmatines
期刊论文
2018, 卷号: 26, 期号: 9, 页码: 2586-2598
作者:
Song, Li
;
Zhang, Hai-Jing
;
Deng, An-Jun
;
Li, Jia
;
Li, Xiang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
Quaternary palmatine
Structure modification
Antibacteria
Anti-ulcerative colitis
Structure-activity relationships
Bis-coumarin Derivatives and their Biological Activities
期刊论文
2018, 卷号: 18, 期号: 2, 页码: 101-113
作者:
Ren Qingcheng
;
Gao Chuan
;
Xu Zhi
;
Xu Yan
;
Liu Ming-Liang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/03
Bis-coumarin
anti-bacterial
antitumor
antiviral
hybrid compounds
structure-activity relationships
Identification of Better Pharmacokinetic Benzothiazinone Derivatives as New Antitubercular Agents
期刊论文
2017, 卷号: 8, 期号: 6, 页码: 636-641
作者:
Lv, Kai
;
You, Xuefu
;
Wang, Bin
;
Wei, Zengquan
;
Chai, Yun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/04
Antitubercular agents
benzothiazinones
spiro-heterocycles
structure-activity relationships
pharmacokinetics
Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis
期刊论文
2017, 卷号: 8, 期号: 5, 页码: 533-537
作者:
Zhao Hongyi
;
Lu Yu
;
Sheng Li
;
Yuan Zishuo
;
Wang Bin
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Antitubercular agents
fluoro-benzoxazinyl-oxazolidinones
structure-activity relationships
drug-resistant tuberculosis (DR-TB)
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