A1c  glycated hemoglobin  AACE  American Association of Clinical Endocrinologists  ACC  acetyl-CoA carboxylase  ADA  American Diabetes Association  Akt/PKB  tyrosine kinase/protein kinase B  AMP  adenosine monophosphate  AMPK  adenosine monophosphate-activated protein  Ang II  angiotensin II  ATP  adenosine triphosphate  BAT  brown adipose tissue  CHOP  CEBP-homologous protein  CEBP  CCAAT enhancer binding protein  CoA  coenzyme A  DPP  Diabetes Prevention Program  EASD  European Association for the Study of Diabetes  eNOS  endothelial nitric oxide synthase  ER  endoplasmic reticulum  FDA  Food and Drug Administration  FFA  free fatty acid  FOXO1  forkhead box protein O1  G6P  glucose 6-phosphate  GDM  gestational diabetes mellitus  GIPR  glucose-dependent insulinotropic polypeptide receptor  GLP-1R  glucagon-like peptide-1 receptor  GLUT1  glucose transporter-1  GLUT4  glucose transporter type 4  GLUTs  glucose transporters  G6P  glucose 6-phosphate, glucose transporter-1  GPR40  G protein-coupled receptor 40  HbA1c  hemoglobin A1c  HGP  hepatic glucose production  HSL  hormone sensitive lipase  IL-6  interleukin 6  INS-1  insulinoma cells in rat  IR  insulin resistance  IRS-1  insulin receptor substrate 1  JNK  c-Jun. N-terminal kinase  Kir6.2  inwardly rectifying potassium/kalium channel  LDs  lipid droplets  LDL  low density lipoprotein  LV  left ventricular  MIN6 cells  mouse insulinoma cells  MAPK  mitogen-activated protein kinases  mPTP  mitochondrial permeability transition pore opening  mTOR  mammalian target of rapamycin  NADPH  nicotinamide adenine dinucleotide phosphate  NF-kappaB  nuclear factors-kappa B  NIT-1 cells  insulinoma cells  p70S6K  p70 ribosomal S6 kinase  PA  palmitic acid  NOS  NADPH oxidase  p38 MAPK  p38 mitogen-activated protein kinase  PA  palmitic acid  PCOS  polycystic ovary syndrome  PGC-1α  peroxisome proliferator-activated receptor-g coactivator-1α  PI3K  phosphatidylinositol 3-kinase  PKB  protein kinase B  PKC  protein kinase C  PPARα  peroxisome-proliferator activated receptor α  PTP  permeability transition pore  RCT  randomized controlled trial  RISK  reperfusion injury salvage kinase  ROS  reactive oxygen species  SERCA2  reticulum sarcoplasmic Ca2 +-ATPase  RISK  reperfusion injury salvage kinase  Smad3  mothers against decapentaplegic homolog 3  SRC-2  steroid receptor coactivator 2  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TGFβ1  transforming growth factor β1  TLR4  Toll-like receptor  TNF-α  tumor necrosis factor α  TR4  testicular receptor 4  UKPDS  United Kingdom Prospective Diabetes Study  VLDL  very low density lipoprotein  Metformin  Pancreatic β Cells  Heart failure  Insulin sensitizer  

Acute myocardial infarction  Endothelial nitric oxide synthase  Inflammatory  Matrix metalloproteinase-2  Mitogen-activated protein kinases  Osthole  

NO  nitric oxide  PGE2  prostaglandin E2  NSAIDs  non-steroidal anti-inflammatory drugs  qRT-PCR  quantitative real-time polymerase chain reaction  LPS  lipopolysaccharide  IFN-γ  interferon γ  G-CSF  granulocyte colony stimulating factor  TNF-α  tumor necrosis factor-α  IL-1β  interleukin-1β  IL-6  interleukin-6  MCP-1  monocyte chemoattractant protein-1  NF-κB  Nuclear factor-κB  IκB  inhibitory protein  IKK  IκB kinase  RPS3  ribosomal protein S3  iNOS  inducible nitric oxide synthase  COX-2  cyclooxygenase-2  PGESs  prostaglandin E2 synthases  mPGES-1  microsomal prostaglandin synthetase-1  mPGES-2  microsomal prostaglandin E synthase-2  cPGES  cytosolic prostaglandin E synthase  MAPK  mitogen-activated protein kinases  ERK  extracellular signal-regulated kinase  JNK  c- Jun N-terminal kinase  PGI2  prostacyclin I2  PGD2  prostaglandin D2  PGF2α  prostaglandin F2α  TXA2  thromboxane A2  Stauntoside B (PubChem CID: 101010462)  Stauntoside B  Cynanchi stauntonii  Lipopolysaccharide  Anti-inflammatory activity  NF-κB  MAPK  

AF-2  activation function-2  AR  androgen receptor  C/EBPα  ccaat-enhancer-binding protein α  CTCF  CCCTC-binding factor  Ddx5  DEAD box protein 5  ERα  estrogen receptor α  GR  glucocorticoid receptor  Hes1  hairy and enhancer of split-1  HP1γ  heterochromatin protein 1γ  JNK  c-Jun N-terminal kinases  lncRNA  long noncoding RNA  MyoD  myogenic differentiation 1  NANOG  homeobox protein NANOG  NR  nuclear receptor(s)  p38 MAPK  mitogen-activated protein kinase  PACT  protein kinase RNA activator  PCOS  polycystic ovary syndrome  PKR  protein kinase RNA-dependent  PPARγ  Peroxisome Proliferator-Activated Receptor gamma  PR  progesterone receptor  PRC2  polycomb repressive complex 2  preTCRα  pre T-cell antigen receptor alpha  Pus1p  pseudouridine synthesis protein  RAR  retinoic acid receptor  RBP-J  recombination signal-binding protein J  RRM  RNA recognition motif  SF-1  steroidogenic factor 1  SHARP  retinoid and thyroid hormone receptors (SMRT)/HDAC1-associated repressor protein  SLIRP  stem-loop loop-interacting RNA RNA-binding protein  SRA  Steroid receptor RNA activator  SRAP  steroid receptor RNA activator protein  SRC-1  steroid receptor coactivator-1  STR  stem-loop structure  TNFα  tumor necrosis factor α  TRBP  transactivation response RNA-binding protein  TrxG  trithorax group  SRA  Long noncoding RNAs  Nuclear receptor  Transcriptional coactivator  

miRNAs  microRNAs  PIAS3  protein inhibitor of activated STAT3  M-CSF  macrophage colony stimulating factor  RANKL  receptor activator of nuclear factor-κB ligand  RANK  receptor activator of NF-κB  OPG  osteoprotegerin  MAPKs  mitogen-activated protein kinases  NFATc1  nuclear factor of activated T cells, calcineurin-dependent 1  PI3K  phosphatidylinositol 3-kinase  3′UTR  3′-untranslated region  MMP2  matrix metalloproteinase 2  MITF  microphthalmia-associated transcription factor  TRAP  tartrate-resistant acid phosphatase  CDS  coding sequences  RT-PCR  reverse transcription-PCR  WT  wild type  MT  mutant  qRT-PCR  quantitative real-time PCR  PIAS  protein inhibitor of activated STAT  STAT3  signal transducer and activator of transcription 3  OSCAR  osteoclast-associated receptor  MicroRNA  Osteoclast  Differentiation  PIAS3  Bone