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科研机构
上海药物研究所 [55]
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期刊论文 [55]
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An enhanced strategy integrating offline two-dimensional separation with data independent acquisition mode and deconvolution: Characterization of metabolites of Uncaria rhynchophylla in rat plasma as a case
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 8
作者:
Li, Haojv
;
Wei, Wenlong
;
Li, Zhenwei
;
Wang, Mengyuan
;
Wei, Xuemei
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/11/04
Off-line 2D separation system
Metabolites characterization in vivo
Data independent acquisition
Multi-dimensional deconvolution
Uncaria rhynchophylla
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
期刊论文
CELL METABOLISM, 2021, 卷号: 33, 期号: 6, 页码: 1221-+
作者:
Liu, Yi
;
Liang, Guanghao
;
Xu, Hongjiao
;
Dong, Wenxin
;
Dong, Ze
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 16
作者:
Xie, Like
;
Wang, Yangyang
;
Yin, Hao
;
Li, Jiajia
;
Xu, Zhou
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/05/24
COVID‐
19
metabolic profiles
quadrupole time‐
of‐
flight mass spectrometry
Tanreqing injection
traditional Chinese medicine
Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity
期刊论文
MOLECULAR PSYCHIATRY, 2021, 卷号: 26, 期号: 4, 页码: 1162-1177
作者:
Chen, Zhong-Guo
;
Wang, Yu-Jun
;
Chen, Ruo-Song
;
Geng, Fan
;
Gan, Chen-Ling
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat, mouse, dog, pig, monkey and human liver microsomes
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 页码: 7
作者:
Li, Hao-Jv
;
Wei, Wen-Long
;
Li, Zhen-Wei
;
Yao, Chang-Liang
;
Wang, Meng-Yuan
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/12/24
Uncaria rhynchophylla
Indole alkaloids
Mass defect filter
Time-staggered targeted ion lists
Metabolite identification
Liver microsomes
Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10, 页码: 16
作者:
Yan, Yi-lin
;
Huang, Zheng-nan
;
Zhu, Zhen
;
Cui, Yang-yan
;
Li, Mei-qian
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/12/24
ten-eleven translocation 1 (TET1)
DNA methylation
bladder cancer
vitamin C
adherens junction-associated protein 1 (AJAP1)
Qualitative and quantitative determination of anaprazole and its major metabolites in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 183, 页码: 10
作者:
Tang, Chongzhuang
;
Li, Liang
;
Ma, Xifeng
;
Wang, Jin
;
Chen, Bo
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2020/07/01
Metabolite identification
LC-MS/MS
UPLC-UV/Q-TOF
Anaprazole
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 1, 页码: 13
作者:
Lin, Ying
;
Xing, Dong
;
Wu, Wen-Biao
;
Xu, Gao-Ya
;
Yu, Li-Fang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
benzofuro[3,2-c]quinolines
3-(2-methoxyphenyl)quinolin-4(1H)one
MV-4-11 cell line
antileukemia activity
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