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浏览/检索结果: 共37条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 24, 页码: 10231-10244 作者:  Liu, Qiufeng;  Huang, Fubao;  Yuan, Xiaojing;  Wang, Kai;  Zou, Yi 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Discovery of a novel calcium-sensitive fluorescent probe for alpha-ketoglutarate 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1683-1690 作者:  Gan, Lin-lin;  Chen, Lin-hai;  Nan, Fa-jun 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 nonalcoholic fatty liver disease  biomarker  alpha-ketoglutarate  fluorescent probe  calcium-sensitive  benzothiazole-coumarin   Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266 作者:  Zheng, Qiangang;  Tang, Shuai;  Fu, Xianlei;  Chen, Ziqi;  Ye, Yan 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 IDH1 inhibitor  Indane amide  Structure-based rational design   Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues 期刊论文 ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 44, 页码: 9352-9361 作者:  Jiang, Hao;  Xing, Jing;  Wang, Chen;  Zhang, Hao;  Yue, Liyan 收藏  |  浏览/下载：110/0  |  提交时间：2019/01/08 New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Yang, Xiuyan;  Zhang, Xi;  Huang, Min;  Song, Kun;  Li, Xuefen 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531 作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Antitumor drug  BRCA1/2  PARP inhibitors  Molecular docking   Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 16, 页码: 7067-7083 作者:  Shi, Ying;  Duan, Yan-Hui;  Ji, Yue-Yang;  Wang, Zhi-Long;  Wu, Yan-Ran 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 16, 页码: 3782-3786 作者:  Cui, Jing;  Peng, Xia;  Gao, Dingding;  Dai, Yang;  Ai, Jing 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 FGFR  Inhibitors  Cellular activity  Fluorine   Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Tang, Yubo;  Tang, Feng;  Yang, Yang;  Zhao, Lei;  Zhou, Hu 收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08 Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 14, 页码: 6289-6304 作者:  Mao, Ruifeng;  Shao, Jingwei;  Zhu, Kongkai;  Zhang, Yuanyuan;  Ding, Hong 收藏  |  浏览/下载：91/0  |  提交时间：2019/01/08