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科研机构
西安交通大学 [1]
昆明植物研究所 [1]
生态环境研究中心 [1]
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期刊论文 [2]
学位论文 [1]
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CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway.
期刊论文
Cellular and molecular biology, 2018, 卷号: 64, 页码: 40-45
作者:
Han Jiming
;
Zhang Lu
;
Zhang Jing
;
Jiang Qiuyu
;
Tong Dongdong
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  |  
浏览/下载:7/0
  |  
提交时间:2019/11/19
CREBRF
Gastric cancer
Proliferation
Cell cycle
AKT signaling pathway.
全氟化合物与脂肪酸靶蛋白的相互作用及干扰效应研究
学位论文
博士, 北京: 中国科学院研究生院, 2014
张连营
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浏览/下载:173/0
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提交时间:2015/06/16
全氟化合物
肝脏型脂肪酸结合蛋白
过氧化物酶体增殖剂激活受体
G-蛋白偶联受体40
信号通路
perfluorinated compounds
liver fatty acid binding protein
peroxisome proliferator-activated receptor γ
G protein coupled receptor 40
signaling pathway.
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
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浏览/下载:26/0
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提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
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