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上海药物研究所 [11]
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期刊论文 [50]
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If small molecules immunotherapy comes, can the prime be far behind?
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218
作者:
Zhang, Jingyu
;
Zhang, Yu
;
Qu, Bingxue
;
Yang, Haiyan
;
Hu, Shengquan
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/06/15
Cancer immunotherapy
Small molecule inhibitors
Combination therapy
Tumor microenvironment
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
A patent review of BRD4 inhibitors (2013-2019)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2020, 卷号: 30, 期号: 1, 页码: 57-81
作者:
Lu, Tian
;
Lu, Wenchao
;
Luo, Cheng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Bromodomain-containing protein 4 (BRD4)
bromodomain and extra-terminal (BET) family
small molecule inhibitors
cancer
patent
therapeutic potential
Computational Insight Into the Small Molecule Intervening PD-L1 Dimerization and the Potential Structure-Activity Relationship
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 15
作者:
Shi, Danfeng
;
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/19
PD-L1
small-molecule inhibitors
molecular dynamics simulation
metadynamics simulation
R-group QSAR
A patent review of arginine methyltransferase inhibitors (2010-2018)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114
作者:
Li, Xiao
;
Wang, Chen
;
Jiang, Hao
;
Luo, Cheng
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
Arginine methylation
Protein arginine methyltransferases (PRMTs)
small molecule inhibitors
drug research and development
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 卷号: 38
作者:
Qin, Jiang-Jiang
;
Yan, Li
;
Zhang, Jia
;
Zhang, Wei-Dong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
STAT3
Triple negative breast cancer
Oncogene
Immune escape
Small molecule inhibitors
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
期刊论文
CELL COMMUNICATION AND SIGNALING, 2019, 卷号: 17, 期号: 1
作者:
Qin, Jiang-Jiang
;
Cheng, Xiang-Dong
;
Zhang, Jia
;
Zhang, Wei-Dong
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/05
Keap1
Nrf2
Pancreatic cancer
Tumor-suppressive and promoting roles
Small molecule activators and inhibitors
Prevention and therapy
Bromodomain-Containing Protein 4: A Druggable Target.
期刊论文
Current drug targets, 2019
作者:
Shi Yingying
;
Liu Jingwen
;
Zhao Yuanyuan
;
Cao Jiaoxian
;
Li Yiming
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
Bromodomain-containing protein 4
coronary heart disease
natural products
pharmacology
small molecule inhibitors
synthetic compounds.
tumor
Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy
期刊论文
2019, 卷号: 27, 期号: 3, 页码: 244-256
作者:
Li, Kui
;
Tian, Hongqi
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/01/03
Small-molecule inhibitors
PD-1
PD-L1 immune checkpoint
targeted therapy
tumour immunotherapy
clinical and preclinical research
Emerging Targets and Latest Proteomics Based Therapeutic Approaches in Neurodegenerative Diseases
期刊论文
CURRENT PROTEIN & PEPTIDE SCIENCE, 2018, 卷号: 19, 期号: 9
作者:
Fatima, Munazza Tamkeen
;
Islam, Zeyaul
;
Ahmad, Ejaj
;
Salahuddin, Parveen
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Protein misfolding
aggregation
chaperones
proteosomes
small molecule inhibitors
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