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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
Context and auto-interaction are all you need: Towards context embedding based QoS prediction via automatic feature interaction for high quality cloud API delivery
期刊论文
Future Generation Computer Systems, 2021, 卷号: 128, 期号: 2022, 页码: 265-281
作者:
Zhen Chen
;
Maosheng Pan
;
Pengfei He
;
Wenchao Qi
;
Linlin Liu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/17
Cloud Api
Qos Prediction
Contextual Information
Automatic Feature Interaction
Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219
作者:
Lu, Tian
;
Li, Yong
;
Lu, Wenchao
;
Spitters, Twgm
;
Fang, Xueyu
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/12/01
Hippo pathway
TEAD3
Covalent inhibitor
Palmitoylation inhibitor
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
期刊论文
HAEMATOLOGICA, 2021, 卷号: 106
作者:
Wang, Aoli
;
Hu, Chen
;
Chen, Cheng
;
Liang, Xiaofei
;
Wang, Beilei
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/04/26
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia
期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 393
作者:
Chen, Cheng
;
Wang, Li
;
Li, Lili
;
Wang, Aoli
;
Huang, Tao
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  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Acute myeloid leukemia (AML)
Drug response
Gene mutations
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:
Wu, Jiaxin
;
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Qi, Ziping
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/11/27
BCR-ABL
PDGFR
chronic myeloid leukemia
kinase inhibitor
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:
Yun Wu
;
Beilei Wang
;
Junjie Wang
;
Qi S(亓爽)
;
Fengming Zou
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/10/20
Overexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 133
作者:
Xie, Yuanlong
;
Deng, Huaxin
;
Wei, Renxiong
;
Sun, Wenchao
;
Qi, Yongjian
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/05
miR-335
Osteosarcoma
Invasion
Migration
Smad nuclear interacting protein 1
Ictal Source Locations and Cortico–Thalamic Connectivity in Childhood Absence Epilepsy: Associations with Treatment Response
期刊论文
Brain Topography, 2019, 卷号: Vol.32 No.1, 页码: 178-191
作者:
Ailiang Miao
;
Yingxin Wang
;
Jing Xiang
;
Qianqian Liu
;
Qiqi Chen
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
Childhood
absence
epilepsy
Magnetoencephalography
Source
location
Cortico–thalamic
network
Treatment
response
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